Dear Editor, We report an interesting case of immunological contact urticaria from eye drops. A‐27‐year‐old woman applied two eye drops for bacterial conjunctivitis: 0.5% levofloxacin hydrate ophthalmic solution (Cravit; Santen Pharmaceutical, Osaka, Japan) and betamethasone sodium phosphate plus fradiomycin sulfate solution (Rinderon‐A; Shionogi, Osaka, Japan). Immediately, she developed conjunctival hyperemia, nasal discharge and sneezing. Subsequently, facial edema, pruritic rash on the trunk and extremities, and mild dyspnea developed. She presented at the emergency clinic of our dermatology department 2 h after the onset. At that time, however, physical examination revealed no overt findings except for mild periorbital edema. We suspected contact urticaria syndrome on the basis of history. Prick testing was performed with the two eye drops (as is), positive control (histamine chlorohydrate solution, 10 mg/mL) and negative control (saline). Solutions were applied to the volar aspect of the left forearm, and were pierced with a Prick‐Lancetter (Ewo Care, Gislaved, Sweden). After 15 min, those droplets were wiped off with soft paper tissue, and reading performed. Positive reactions for Cravit ophthalmic solution 0.5% (6‐mm wheal in diameter) and histamine chlorohydrate solution, and negative for Rinderon‐A solution and saline were noted (Fig. ). All 10 normal controls were prick
The Journal of Dermatology – Wiley
Published: Jan 1, 2013
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