In a joint study, 2061 patterns (1346 women and 715 men) were patch tested with chlorhexidine gluconate 1% in Water. included in a standard lest series. 4H patients (2.3%) showed a positive reaction. These were relatively marc common in men (3.2%) than in women (1.9%), Positive reactions were most common in patients with leg eczema (6.8%) or leg ulcer (10.9%). Of the 48 patients who were patch test positive. 14 (2 with leg ulcer) were retested with chlorhexidine gluconate 0.01 and 1%. Only one with a leg ulcer was positive. These findings indicate that false positive reactions, known as “the incited skin syndrome”, may arise from testing eczema patients in a standard series The sensitizing potential of chlorhexidine may be very low, but the potential in patients with an eczema or ulcer of the leg has to be further evaluated.
Contact Dermatitis – Wiley
Published: Jul 1, 1985
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