Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Complex regional haemodynamic effects of anandamide in conscious rats

Complex regional haemodynamic effects of anandamide in conscious rats Experiments were carried out in conscious, chronically instrumented, male, Sprague‐Dawley rats to delineate the regional haemodynamic effects of the putative endogenous cannabinoid, anandamide, (0.075 – 3 mg kg−1), and to dissect some of the mechanisms involved. At all doses of anandamide, there was a significant, short‐lived increase in mean arterial blood pressure associated with vasoconstriction in renal, mesenteric and hindquarters vascular beds. The higher doses (2.5 and 3 mg kg−1), caused an initial, marked bradycardia accompanied, in some animals, by a fall in arterial blood pressure which preceded the hypertension. In addition, after the higher doses of anandamide, the hindquarters vasoconstriction was followed by vasodilatation. Although some of the effects described above resembled those of 5‐HT (25 μg kg−1), the bradycardia and hypotensive actions of the latter were abolished by the 5HT3‐receptor antagonist, azasetron, whereas those of anandamide were generally unaffected. None of the cardiovascular actions of anandamide were influenced by the CB1‐receptor antagonist, AM 251, but its bradycardic effect was sensitive to atropine, and its hindquarters vasodilator action was suppressed by the β2‐adrenoceptor antagonist, ICI 118551. The results differ, in several aspects, from those previously reported in anaesthetized animals, and underscore the important impact anaesthesia can have on responses to anandamide. British Journal of Pharmacology (2002) 135, 1889–1896; doi:10.1038/sj.bjp.0704649 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

Complex regional haemodynamic effects of anandamide in conscious rats

Loading next page...
 
/lp/wiley/complex-regional-haemodynamic-effects-of-anandamide-in-conscious-rats-0F2VxFthdc
Publisher
Wiley
Copyright
2002 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1038/sj.bjp.0704649
pmid
11959791
Publisher site
See Article on Publisher Site

Abstract

Experiments were carried out in conscious, chronically instrumented, male, Sprague‐Dawley rats to delineate the regional haemodynamic effects of the putative endogenous cannabinoid, anandamide, (0.075 – 3 mg kg−1), and to dissect some of the mechanisms involved. At all doses of anandamide, there was a significant, short‐lived increase in mean arterial blood pressure associated with vasoconstriction in renal, mesenteric and hindquarters vascular beds. The higher doses (2.5 and 3 mg kg−1), caused an initial, marked bradycardia accompanied, in some animals, by a fall in arterial blood pressure which preceded the hypertension. In addition, after the higher doses of anandamide, the hindquarters vasoconstriction was followed by vasodilatation. Although some of the effects described above resembled those of 5‐HT (25 μg kg−1), the bradycardia and hypotensive actions of the latter were abolished by the 5HT3‐receptor antagonist, azasetron, whereas those of anandamide were generally unaffected. None of the cardiovascular actions of anandamide were influenced by the CB1‐receptor antagonist, AM 251, but its bradycardic effect was sensitive to atropine, and its hindquarters vasodilator action was suppressed by the β2‐adrenoceptor antagonist, ICI 118551. The results differ, in several aspects, from those previously reported in anaesthetized animals, and underscore the important impact anaesthesia can have on responses to anandamide. British Journal of Pharmacology (2002) 135, 1889–1896; doi:10.1038/sj.bjp.0704649

Journal

British Journal of PharmacologyWiley

Published: Apr 1, 2002

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month