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Comparison of Blood Stored in ACD and in a Solution Containing Heparin, Phosphate, Glucose and Adenine

Comparison of Blood Stored in ACD and in a Solution Containing Heparin, Phosphate, Glucose and... Duplicate blood samples were obtained from six healthy young males, one aliquot was collected in ACD and one aliquot in a solution of heparin‐glucose‐phosphate‐adenine (HGPA). All were stored under blood bank conditions for a total of four weeks. The HGPA samples maintained their ATP and nucleotide adenine levels much better than the ACD samples and had generally higher pH's and faster rates of glycolysis. Their osmotic fragility and plasma K+ levels were similar to those of the ACD samples. Because there was considerably more hemolysis in the HGPA samples than in the ACD samples and in the absence of red cell survival data, the HGPA system is not recommended at this time as a substitute for the ACD system but as a comparative system to reveal metabolic shortcomings of the ACD storage system. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transfusion Wiley

Comparison of Blood Stored in ACD and in a Solution Containing Heparin, Phosphate, Glucose and Adenine

Transfusion , Volume 4 (4) – Jul 8, 1964

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Publisher
Wiley
Copyright
1964 AABB
ISSN
0041-1132
eISSN
1537-2995
DOI
10.1111/j.1537-2995.1964.tb02871.x
Publisher site
See Article on Publisher Site

Abstract

Duplicate blood samples were obtained from six healthy young males, one aliquot was collected in ACD and one aliquot in a solution of heparin‐glucose‐phosphate‐adenine (HGPA). All were stored under blood bank conditions for a total of four weeks. The HGPA samples maintained their ATP and nucleotide adenine levels much better than the ACD samples and had generally higher pH's and faster rates of glycolysis. Their osmotic fragility and plasma K+ levels were similar to those of the ACD samples. Because there was considerably more hemolysis in the HGPA samples than in the ACD samples and in the absence of red cell survival data, the HGPA system is not recommended at this time as a substitute for the ACD system but as a comparative system to reveal metabolic shortcomings of the ACD storage system.

Journal

TransfusionWiley

Published: Jul 8, 1964

References

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