Comparative study of combined bevacizumab/targeted photocoagulation vs bevacizumab alone for macular oedema in ischaemic branch retinal vein occlusions

Comparative study of combined bevacizumab/targeted photocoagulation vs bevacizumab alone for... Purpose To investigate whether targeted retinal photocoagulation (TRP) of peripheral non‐perfused areas (NPAs) could prevent the recurrence of macular oedema (ME) due to branch retinal vein occlusion (BRVO) after intravitreal bevacizumab injection (IVB). Methods Eyes received 1.25 mg IVB only (IVB group) or combined with TRP (IVB + TRP group) of NPAs, more than 5 disc areas identified by fluorescein angiography in the patients with ME secondary to BRVO. Best‐corrected visual acuity (BCVA) and central retinal thickness (CRT) determined by optical coherence tomography were measured every month for 6 months. Results Thirty‐eight patients were enrolled and randomized to IVB group (n = 19) and IVB + TRP group (n = 19). Both groups showed similar thinning in CRT at 1 week after IVB, IVB + TRP group maintained thinner retina at 2 (p = 0.0072) and 3 (p = 0.0086) months compared with IVB group in whom turned to thickened almost back to baseline at 3 months. The number of reinjections in IVB group (1.58 ± 0.69) was significantly greater (p = 0.0025) than that in IVB + TRP group (0.83 ± 0.62). BCVA significantly improved at 6 month in IVB + TRP group (p = 0.015), but not in IVB group. Conclusion TRP of NPAs reduced the amount of ME recurrence following IVB compared to IVB alone. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Ophthalmologica Wiley

Comparative study of combined bevacizumab/targeted photocoagulation vs bevacizumab alone for macular oedema in ischaemic branch retinal vein occlusions

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Publisher
Wiley
Copyright
Copyright © 2016 Acta Ophthalmologica Scandinavica Foundation
ISSN
1755-375X
eISSN
1755-3768
DOI
10.1111/aos.12721
pmid
25989706
Publisher site
See Article on Publisher Site

Abstract

Purpose To investigate whether targeted retinal photocoagulation (TRP) of peripheral non‐perfused areas (NPAs) could prevent the recurrence of macular oedema (ME) due to branch retinal vein occlusion (BRVO) after intravitreal bevacizumab injection (IVB). Methods Eyes received 1.25 mg IVB only (IVB group) or combined with TRP (IVB + TRP group) of NPAs, more than 5 disc areas identified by fluorescein angiography in the patients with ME secondary to BRVO. Best‐corrected visual acuity (BCVA) and central retinal thickness (CRT) determined by optical coherence tomography were measured every month for 6 months. Results Thirty‐eight patients were enrolled and randomized to IVB group (n = 19) and IVB + TRP group (n = 19). Both groups showed similar thinning in CRT at 1 week after IVB, IVB + TRP group maintained thinner retina at 2 (p = 0.0072) and 3 (p = 0.0086) months compared with IVB group in whom turned to thickened almost back to baseline at 3 months. The number of reinjections in IVB group (1.58 ± 0.69) was significantly greater (p = 0.0025) than that in IVB + TRP group (0.83 ± 0.62). BCVA significantly improved at 6 month in IVB + TRP group (p = 0.015), but not in IVB group. Conclusion TRP of NPAs reduced the amount of ME recurrence following IVB compared to IVB alone.

Journal

Acta OphthalmologicaWiley

Published: May 1, 2016

Keywords: ; ; ; ; ; ; ; ;

References

  • Intravitreal triamcinolone compared with macular laser grid photocoagulation for the treatment of cystoid macular edema
    Avitabile, Avitabile; Longo, Longo; Reibaldi, Reibaldi
  • Retinal vein occlusion: beyond the acute event
    Ehlers, Ehlers; Fekrat, Fekrat
  • Autologous serum eye drops diluted with sodium hyaluronate: clinical and experimental comparative study
    Lopez‐Garcia, Lopez‐Garcia; Garcia‐Lozano, Garcia‐Lozano; Rivas, Rivas; Ramirez, Ramirez; Raposo, Raposo; Mendez, Mendez
  • Pathogenesis of macular edema with branch retinal vein occlusion and intraocular levels of vascular endothelial growth factor and interleukin‐6
    Noma, Noma; Funatsu, Funatsu; Yamasaki, Yamasaki
  • Changes of aqueous vascular endothelial growth factor and interleukin‐6 after intravitreal triamcinolone for branch retinal vein occlusion
    Park, Park; Ahn, Ahn
  • Ranibizumab for Branch Retinal Vein Occlusion Associated Macular Edema Study (RABAMES): six‐month results of a prospective randomized clinical trial
    Pielen, Pielen; Mirshahi, Mirshahi; Feltgen, Feltgen

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