Comparative sequence analysis of duck and human hepatitis B virus genomes

Comparative sequence analysis of duck and human hepatitis B virus genomes We have cloned and sequenced an infectious, functionally active genome of a duck hepatitis B virus (DHBV). It is 3,021 base pairs (bp) in length and shows little DNA sequence homology to the genome of human hepatitis B virus (HBV). However, the amino acid sequences of predicted viral gene products are similar between DHBV and HBV, and the genome organization present in DHBV reflects that of HBV. As in the mammalian virus the long minus strand of the DHBV genome encodes three long overlapping reading frames designated as P, S, and C. The fourth open reading frame, termed X, is absent in DHBV. A comparison with a sequence of a second DHBV isolate (Mandart et al, Journal of Virology 49:782–792, 1984) revealed a nucleotide sequence variation of 5.6% and confirmed the presented overall gene organization of DHBV. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Virology Wiley

Comparative sequence analysis of duck and human hepatitis B virus genomes

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Publisher
Wiley
Copyright
Copyright © 1985 Wiley‐Liss, Inc., A Wiley Company
ISSN
0146-6615
eISSN
1096-9071
D.O.I.
10.1002/jmv.1890150402
Publisher site
See Article on Publisher Site

Abstract

We have cloned and sequenced an infectious, functionally active genome of a duck hepatitis B virus (DHBV). It is 3,021 base pairs (bp) in length and shows little DNA sequence homology to the genome of human hepatitis B virus (HBV). However, the amino acid sequences of predicted viral gene products are similar between DHBV and HBV, and the genome organization present in DHBV reflects that of HBV. As in the mammalian virus the long minus strand of the DHBV genome encodes three long overlapping reading frames designated as P, S, and C. The fourth open reading frame, termed X, is absent in DHBV. A comparison with a sequence of a second DHBV isolate (Mandart et al, Journal of Virology 49:782–792, 1984) revealed a nucleotide sequence variation of 5.6% and confirmed the presented overall gene organization of DHBV.

Journal

Journal of Medical VirologyWiley

Published: Aug 1, 1985

References

  • Viral hepatitis: Report on a WHO informal consultation
    McCollum, McCollum; Zuckerman, Zuckerman

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