Commentary to the article lung function not affected by asbestos exposure in workers with normal Computed Tomography scan, by Schikowsky, Felten, et al., 2017

Commentary to the article lung function not affected by asbestos exposure in workers with normal... Schikowsky et al. conducted a cross‐sectional study of 207 selected asbestos workers from a power plant with a mean exposure of 49 (0.1‐844.9) fiber‐years, mean exposure duration of 21.4 (1‐42) years, and a mean latency period of 36.2 (13‐60) years. Their results include a statistically significant association of Forced Vital Capacity (FVC), Forced Expiratory Volume in 1 second (FEV1), and airway resistance with smoking and with Body Mass Index (BMI). The only asbestos‐related association they describe is the carbon monoxide transfer coefficient (KCO), which is the ratio of the diffusing capacity for carbon monoxide (DLCO) and the alveolar volume (VA), (DLCO/VA) and which is reported to be negatively associated with time elapsed since the end of asbestos exposure; however, the authors argue that “these results may also point to an inaccurate adaptation of the DLCO/VA reference values …” No such association is described for cumulative asbestos exposure or duration of asbestos exposure. They stress, in the introduction as well as in the discussion, that “the overlying effect of ageing and a possible genetically determined predisposition for a specific patho‐physiological reaction resulting in decreased lung function parameters are frequently combined with the influencing factor of high BMI.”COMMENT 1While Schikowsky et http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Industrial Medicine Wiley

Commentary to the article lung function not affected by asbestos exposure in workers with normal Computed Tomography scan, by Schikowsky, Felten, et al., 2017

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0271-3586
eISSN
1097-0274
D.O.I.
10.1002/ajim.22772
Publisher site
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Abstract

Schikowsky et al. conducted a cross‐sectional study of 207 selected asbestos workers from a power plant with a mean exposure of 49 (0.1‐844.9) fiber‐years, mean exposure duration of 21.4 (1‐42) years, and a mean latency period of 36.2 (13‐60) years. Their results include a statistically significant association of Forced Vital Capacity (FVC), Forced Expiratory Volume in 1 second (FEV1), and airway resistance with smoking and with Body Mass Index (BMI). The only asbestos‐related association they describe is the carbon monoxide transfer coefficient (KCO), which is the ratio of the diffusing capacity for carbon monoxide (DLCO) and the alveolar volume (VA), (DLCO/VA) and which is reported to be negatively associated with time elapsed since the end of asbestos exposure; however, the authors argue that “these results may also point to an inaccurate adaptation of the DLCO/VA reference values …” No such association is described for cumulative asbestos exposure or duration of asbestos exposure. They stress, in the introduction as well as in the discussion, that “the overlying effect of ageing and a possible genetically determined predisposition for a specific patho‐physiological reaction resulting in decreased lung function parameters are frequently combined with the influencing factor of high BMI.”COMMENT 1While Schikowsky et

Journal

American Journal of Industrial MedicineWiley

Published: Jan 1, 2018

References

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