Combined loss of HLA I and HLA II expression is more common in the non‐GCB type of diffuse large B cell lymphoma

Combined loss of HLA I and HLA II expression is more common in the non‐GCB type of diffuse... Sir: As an immune escape mechanism, tumour cells may down‐regulate expression of human leucocyte antigens (HLA). Loss of HLA classes I and II has been described in various subtypes of diffuse large B cell lymphoma (DLBCL), including the not otherwise specified (NOS) subgroup. We analysed HLA classes I and II expression in DLBCL‐NOS to investigate whether there is an association between HLA expression, cell of origin (COO) and the recently reported FoxP1 expression in non‐GCB DLBCL.Seventy‐seven cases of DLBCL‐NOS with an almost exclusively nodal presentation were classified for COO by immunohistochemistry (IHC) according to the Hans algorithm as germinal centre B (GCB) cell‐type (n = 42) or non‐GCB‐type (n = 35) (Table ). Clinical data available from 67 cases indicated a histologically confirmed pre‐existent or concurrent indolent lymphoma in 16 patients, i.e. 13 follicular lymphoma, two marginal zone lymphoma and one chronic lymphocytic leukaemia. Expression of HLA and FoxP1 was assessed by IHC; methods are described in the Supporting Information.Features of DLBCL‐NOS casesCharacteristicNon‐GCB (35)GCB (42)P‐valueMale (%)23 (66)24 (57)Median age (years; range)66 (9–85)56 (14–77)Ann Arbor stageI/II (%)6 (17)18 (43)III/IV (%)26 (74)18 (43)Unknown (%)3 (9)6 (14)IPI0–1 (%)5 (14)13 (31)2–3 (%)19 (55)18 (43)4–5 (%)7 (20)1 (2)Unknown (%)4 (11)10 (24)Transformation (%)2 (6)14 (33)<0.01HLA http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Histopathology Wiley

Combined loss of HLA I and HLA II expression is more common in the non‐GCB type of diffuse large B cell lymphoma

Loading next page...
 
/lp/wiley/combined-loss-of-hla-i-and-hla-ii-expression-is-more-common-in-the-non-xRuKYRJBQt
Publisher
Wiley
Copyright
Copyright © 2018 John Wiley & Sons Ltd
ISSN
0309-0167
eISSN
1365-2559
D.O.I.
10.1111/his.13445
Publisher site
See Article on Publisher Site

Abstract

Sir: As an immune escape mechanism, tumour cells may down‐regulate expression of human leucocyte antigens (HLA). Loss of HLA classes I and II has been described in various subtypes of diffuse large B cell lymphoma (DLBCL), including the not otherwise specified (NOS) subgroup. We analysed HLA classes I and II expression in DLBCL‐NOS to investigate whether there is an association between HLA expression, cell of origin (COO) and the recently reported FoxP1 expression in non‐GCB DLBCL.Seventy‐seven cases of DLBCL‐NOS with an almost exclusively nodal presentation were classified for COO by immunohistochemistry (IHC) according to the Hans algorithm as germinal centre B (GCB) cell‐type (n = 42) or non‐GCB‐type (n = 35) (Table ). Clinical data available from 67 cases indicated a histologically confirmed pre‐existent or concurrent indolent lymphoma in 16 patients, i.e. 13 follicular lymphoma, two marginal zone lymphoma and one chronic lymphocytic leukaemia. Expression of HLA and FoxP1 was assessed by IHC; methods are described in the Supporting Information.Features of DLBCL‐NOS casesCharacteristicNon‐GCB (35)GCB (42)P‐valueMale (%)23 (66)24 (57)Median age (years; range)66 (9–85)56 (14–77)Ann Arbor stageI/II (%)6 (17)18 (43)III/IV (%)26 (74)18 (43)Unknown (%)3 (9)6 (14)IPI0–1 (%)5 (14)13 (31)2–3 (%)19 (55)18 (43)4–5 (%)7 (20)1 (2)Unknown (%)4 (11)10 (24)Transformation (%)2 (6)14 (33)<0.01HLA

Journal

HistopathologyWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off