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Combined loss of HLA I and HLA II expression is more common in the non‐GCB type of diffuse large B cell lymphoma

Combined loss of HLA I and HLA II expression is more common in the non‐GCB type of diffuse large... Sir: As an immune escape mechanism, tumour cells may down‐regulate expression of human leucocyte antigens (HLA). Loss of HLA classes I and II has been described in various subtypes of diffuse large B cell lymphoma (DLBCL), including the not otherwise specified (NOS) subgroup. We analysed HLA classes I and II expression in DLBCL‐NOS to investigate whether there is an association between HLA expression, cell of origin (COO) and the recently reported FoxP1 expression in non‐GCB DLBCL.Seventy‐seven cases of DLBCL‐NOS with an almost exclusively nodal presentation were classified for COO by immunohistochemistry (IHC) according to the Hans algorithm as germinal centre B (GCB) cell‐type (n = 42) or non‐GCB‐type (n = 35) (Table ). Clinical data available from 67 cases indicated a histologically confirmed pre‐existent or concurrent indolent lymphoma in 16 patients, i.e. 13 follicular lymphoma, two marginal zone lymphoma and one chronic lymphocytic leukaemia. Expression of HLA and FoxP1 was assessed by IHC; methods are described in the Supporting Information.Features of DLBCL‐NOS casesCharacteristicNon‐GCB (35)GCB (42)P‐valueMale (%)23 (66)24 (57)Median age (years; range)66 (9–85)56 (14–77)Ann Arbor stageI/II (%)6 (17)18 (43)III/IV (%)26 (74)18 (43)Unknown (%)3 (9)6 (14)IPI0–1 (%)5 (14)13 (31)2–3 (%)19 (55)18 (43)4–5 (%)7 (20)1 (2)Unknown (%)4 (11)10 (24)Transformation (%)2 (6)14 (33)<0.01HLA http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Histopathology Wiley

Combined loss of HLA I and HLA II expression is more common in the non‐GCB type of diffuse large B cell lymphoma

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References (7)

Publisher
Wiley
Copyright
Copyright © 2018 John Wiley & Sons Ltd
ISSN
0309-0167
eISSN
1365-2559
DOI
10.1111/his.13445
Publisher site
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Abstract

Sir: As an immune escape mechanism, tumour cells may down‐regulate expression of human leucocyte antigens (HLA). Loss of HLA classes I and II has been described in various subtypes of diffuse large B cell lymphoma (DLBCL), including the not otherwise specified (NOS) subgroup. We analysed HLA classes I and II expression in DLBCL‐NOS to investigate whether there is an association between HLA expression, cell of origin (COO) and the recently reported FoxP1 expression in non‐GCB DLBCL.Seventy‐seven cases of DLBCL‐NOS with an almost exclusively nodal presentation were classified for COO by immunohistochemistry (IHC) according to the Hans algorithm as germinal centre B (GCB) cell‐type (n = 42) or non‐GCB‐type (n = 35) (Table ). Clinical data available from 67 cases indicated a histologically confirmed pre‐existent or concurrent indolent lymphoma in 16 patients, i.e. 13 follicular lymphoma, two marginal zone lymphoma and one chronic lymphocytic leukaemia. Expression of HLA and FoxP1 was assessed by IHC; methods are described in the Supporting Information.Features of DLBCL‐NOS casesCharacteristicNon‐GCB (35)GCB (42)P‐valueMale (%)23 (66)24 (57)Median age (years; range)66 (9–85)56 (14–77)Ann Arbor stageI/II (%)6 (17)18 (43)III/IV (%)26 (74)18 (43)Unknown (%)3 (9)6 (14)IPI0–1 (%)5 (14)13 (31)2–3 (%)19 (55)18 (43)4–5 (%)7 (20)1 (2)Unknown (%)4 (11)10 (24)Transformation (%)2 (6)14 (33)<0.01HLA

Journal

Histopathology – Wiley

Published: Jan 1, 2018

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