Combination of alfacalcidol and calcium improved handgrip strength and mobility among Indonesian older women: A randomized controlled trial

Combination of alfacalcidol and calcium improved handgrip strength and mobility among Indonesian... IntroductionFalls are a major threat among the older population, as they cause morbidity and mortality, as well as expensive healthcare costs. After menopause, women have a greater risk of falls than men. One indispensable intrinsic factor is reduced muscle strength. Reduced muscle mass occurs in almost 30% of the population aged >60 years, and more than 50% in those who aged >80 years. Some studies have shown the correlation between vitamin D deficiency and the loss of muscle strength, as well as its function in older people. A study in Indonesia by Rinaldi et al. found a positive correlation between 25(OH)D3 serum level and muscle strength of femoral quadriceps in older women (r = 0.327; P = 0.009).Despite being located in a region with supposedly abundant sunlight exposure, older adults in Indonesia are still at great risk of vitamin D deficiency, as they have reduced synthesis of 25(OH)D3 in their skin, low vitamin D in their diet, lack of sunlight exposure, reduced hydroxylation in their kidneys and polymorphism of vitamin D receptors (VDR). A study carried out by Setiati et al. found that the prevalence of vitamin D deficiency in Indonesian older women living in nursing homes was 35.1%. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Geriatrics & Gerontology International Wiley

Combination of alfacalcidol and calcium improved handgrip strength and mobility among Indonesian older women: A randomized controlled trial

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Japan Geriatrics Society
ISSN
1444-1586
eISSN
1447-0594
D.O.I.
10.1111/ggi.13201
Publisher site
See Article on Publisher Site

Abstract

IntroductionFalls are a major threat among the older population, as they cause morbidity and mortality, as well as expensive healthcare costs. After menopause, women have a greater risk of falls than men. One indispensable intrinsic factor is reduced muscle strength. Reduced muscle mass occurs in almost 30% of the population aged >60 years, and more than 50% in those who aged >80 years. Some studies have shown the correlation between vitamin D deficiency and the loss of muscle strength, as well as its function in older people. A study in Indonesia by Rinaldi et al. found a positive correlation between 25(OH)D3 serum level and muscle strength of femoral quadriceps in older women (r = 0.327; P = 0.009).Despite being located in a region with supposedly abundant sunlight exposure, older adults in Indonesia are still at great risk of vitamin D deficiency, as they have reduced synthesis of 25(OH)D3 in their skin, low vitamin D in their diet, lack of sunlight exposure, reduced hydroxylation in their kidneys and polymorphism of vitamin D receptors (VDR). A study carried out by Setiati et al. found that the prevalence of vitamin D deficiency in Indonesian older women living in nursing homes was 35.1%.

Journal

Geriatrics & Gerontology InternationalWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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