INTRODUCTIONGeneralized tonic‐clonic status epilepticus (GTC‐SE) is considered to have a high risk of causing poor functional outcome in survivors, including cognitive impairment. Previous studies indicate that memory is the cognitive function most prone to decay in patients with epilepsy. The association is strongest for generalized tonic‐clonic seizures and correlates with seizure load. Experimental studies have demonstrated that the neocortex, thalamus, cerebellum and hippocampus are vulnerable to damage from GTC‐SE. The hippocampus, essential for memory formation and retrieval, seems particularly sensitive to prolonged seizures. MRI studies in humans have shown hippocampal oedema, sometimes followed by sclerosis. Neuropathology studies in patients dying after SE have found distinct hippocampal neuronal damage.It has been argued that intellectual prognosis in otherwise normal children with focal epilepsies is little influenced by an unprovoked GTC‐SE. However, 1 year after febrile SE, children had significantly smaller hippocampi than controls with simple febrile seizures. They also tended to have delayed motor and language development. Impaired cognitive function after GTC‐SE has been detected in children without previous developmental delay.Impaired cognitive function after GTC‐SE has been reported in adults. Dysfunctions may partially subside during weeks or months following GTC‐SE, which also has been suggested after focal SE. There are few systematic
Acta Neurologica Scandinavica – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera