Coexpression of Glucagon‐Like Peptide‐1 (GLP‐1) Receptor, Vasopressin, and Oxytocin mRNAs in Neurons of the Rat Hypothalamic Supraoptic and Paraventricular Nuclei

Coexpression of Glucagon‐Like Peptide‐1 (GLP‐1) Receptor, Vasopressin, and Oxytocin mRNAs... Abstract : This study was designed to gain better insight into the relationship between glucagon‐like peptide‐1 (GLP‐1) (7‐36) amide and vasopressin (AVP) and oxytocin (OX). In situ hybridization histochemistry revealed colocalization of the mRNAs for GLP‐1 receptor, AVP, and OX in neurons of the hypothalamic supraoptic and paraventricular nuclei. To determine whether GLP‐1(7‐36)amide alters AVP and/or OX release, both in vivo and in vitro experimental study designs were used. In vivo, intravenous administration of 1 μg of GLP‐1(7‐36)amide into the jugular vein significantly decreased plasma AVP and OX concentrations. In vitro incubation of the neurohypophysis with either 0.1 or 1 μg of GLP‐1(7‐36)amide did not modify the release of AVP. However, addition of 1 μg of GLP‐1(7‐36)amide to the incubation medium increased slightly the secretion of OX. The coexpression of GLP‐1 receptor and AVP mRNAs in hypothalamic supraoptic and paraventricular nuclei gives further support to the already reported central effects of GLP‐1(7‐36)amide on AVP. Our findings also suggest a dual secretory response of AVP and OX to the effect of GLP‐1(7‐36)amide, which most likely is related to the amount and/or the route of peptide administration. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

Coexpression of Glucagon‐Like Peptide‐1 (GLP‐1) Receptor, Vasopressin, and Oxytocin mRNAs in Neurons of the Rat Hypothalamic Supraoptic and Paraventricular Nuclei

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© International Society for Neurochemistry
ISSN
0022-3042
eISSN
1471-4159
D.O.I.
10.1046/j.1471-4159.1999.0720010.x
Publisher site
See Article on Publisher Site

Abstract

Abstract : This study was designed to gain better insight into the relationship between glucagon‐like peptide‐1 (GLP‐1) (7‐36) amide and vasopressin (AVP) and oxytocin (OX). In situ hybridization histochemistry revealed colocalization of the mRNAs for GLP‐1 receptor, AVP, and OX in neurons of the hypothalamic supraoptic and paraventricular nuclei. To determine whether GLP‐1(7‐36)amide alters AVP and/or OX release, both in vivo and in vitro experimental study designs were used. In vivo, intravenous administration of 1 μg of GLP‐1(7‐36)amide into the jugular vein significantly decreased plasma AVP and OX concentrations. In vitro incubation of the neurohypophysis with either 0.1 or 1 μg of GLP‐1(7‐36)amide did not modify the release of AVP. However, addition of 1 μg of GLP‐1(7‐36)amide to the incubation medium increased slightly the secretion of OX. The coexpression of GLP‐1 receptor and AVP mRNAs in hypothalamic supraoptic and paraventricular nuclei gives further support to the already reported central effects of GLP‐1(7‐36)amide on AVP. Our findings also suggest a dual secretory response of AVP and OX to the effect of GLP‐1(7‐36)amide, which most likely is related to the amount and/or the route of peptide administration.

Journal

Journal of NeurochemistryWiley

Published: Jan 1, 1999

Keywords: ; ; ; ; ; ;

References

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