Few clinical cases of pemphigus herpetiformis (PH) associated with neoplasia have been reported. We describe the first case, to our knowledge, of simultaneous PH and extramammary Paget disease (EMPD).A 72‐year‐old man presented with a 6‐month history of diffuse erythema, papules, vesicles and bullae, some of which were annular in shape (Fig. a), and an erythematous skin rash with exudation and ulcers on the scrotum and base of the penis (Fig. a). All lesions were severely pruritic. Nikolsky sign was negative. The mucous membranes were clear, and no lymphadenopathy was found. Radiographs of the chest were clear, and colonoscopy and ultrasonography findings of the abdominal and uropoietic systems were normal.(a) Erythema and annular‐shaped vesicles on the inside of the right knee. (b) Neutrophilic and eosinophilic spongiosis with an intraepidermal vesicle containing neutrophils and eosinophils (haematoxylin and eosin, original magnification × 200). (c,d) Deposition of IgG and C3 on the cell surface of keratinocytes (original magnification × 400).(a) An erythematous skin rash with exudation and ulceration on the scrotum and base of the penis. (b) Intraepidermal proliferation of large, round cells with ample amphophilic cytoplasm (haematoxylin and eosin, original magnification × 200). (c–e) Paget cells were (c,d) positive for cytokeratin (CK)7
Clinical & Experimental Dermatology – Wiley
Published: Jan 1, 2018
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