Few clinical cases of pemphigus herpetiformis (PH) associated with neoplasia have been reported. We describe the first case, to our knowledge, of simultaneous PH and extramammary Paget disease (EMPD).A 72‐year‐old man presented with a 6‐month history of diffuse erythema, papules, vesicles and bullae, some of which were annular in shape (Fig. a), and an erythematous skin rash with exudation and ulcers on the scrotum and base of the penis (Fig. a). All lesions were severely pruritic. Nikolsky sign was negative. The mucous membranes were clear, and no lymphadenopathy was found. Radiographs of the chest were clear, and colonoscopy and ultrasonography findings of the abdominal and uropoietic systems were normal.(a) Erythema and annular‐shaped vesicles on the inside of the right knee. (b) Neutrophilic and eosinophilic spongiosis with an intraepidermal vesicle containing neutrophils and eosinophils (haematoxylin and eosin, original magnification × 200). (c,d) Deposition of IgG and C3 on the cell surface of keratinocytes (original magnification × 400).(a) An erythematous skin rash with exudation and ulceration on the scrotum and base of the penis. (b) Intraepidermal proliferation of large, round cells with ample amphophilic cytoplasm (haematoxylin and eosin, original magnification × 200). (c–e) Paget cells were (c,d) positive for cytokeratin (CK)7
Clinical & Experimental Dermatology – Wiley
Published: Jan 1, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.
Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.
It’s easy to organize your research with our built-in tools.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera