Brain and Behavior. 2018;8:e00969.
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Cntn6 deficiency impairs allocentric navigation in mice
* | Yiliang Xu
* | Tian Zhao
| Kazutada Watanabe
| Haihong Ye
provided the original work is properly cited.
©2018TheAuthors. Brain and BehaviorpublishedbyWileyPeriodicals,Inc.
Importation and Development of High-
CIT&TCD20130339); National Natural
Introduction: CNTN6 is an immunoglobulin domain- containing cell adhesion mole-
cule that belongs to the contactin family. It is involved in the development of the
nervous system. We aim to determine the effect of Cntn6 deficiency on the allocen-
tric navigation in mice.
Methods: We recorded the travel distance and escape time of wild- type and Cntn6
mutant male and female mice in the Morris water maze task according to the
Results: There was hardly any Cntn6 expression in the hippocampus of postnatal day
male mice failed to shorten the escape time to reach platform on the third
significant difference in both escape time and travel distance to the platform among
male mice were normal. In the spatial relearn-
male mice showed no difference in escape time to the
platformcomparedtothewild-typemalemice,whileCntn6 deficient female mice re-
Conclusions: Cntn6 is expressed in the developing hippocampus in mice. Cntn6 defi-
ciencyaffectsspatiallearningandmemory,indicatingthatCntn6 plays a role in the
development of hippocampus and affects allocentric navigation of the animals.
1 | INTRODUCTION
Development of the central nervous system is dependent on the
highly coordinated interactions between diverse cell types. Cell
diate cell–cell and cell–extracellular matrix interactions in multiple
neural developmental processes (Doving & Trotier, 1998; Schaal
etal., 2003), including neuronal migration, neurite outgrowth,