Clinical use of triamcinolone acetonide in the horse (205 cases) and the incidence of glucocorticoid‐induced laminitis associated with its use

Clinical use of triamcinolone acetonide in the horse (205 cases) and the incidence of... Clinical use of triamcinolone acetonide in the horse (205 cases) and the incidence of glucocorticoid-induced laminitis associated with its use M. J. MCCLUSKEY* AND P. B. KAVENAGH Kavenagh & McCluskey Equine Clinic, 6 Tanner Street, Geelong, Victoria 3219, Australia. Keywords: horse; triamcinolone; laminitis; glucocorticoid Introduction Glucocorticoids have been implicated as a cause of ‘steroidinduced laminitis’ in horses for more than 25 years (Vernimb et al. 1977; Lose 1980; Lawrence et al. 1985; Eustace and Redden 1990; Harkins et al. 1993). It has previously been observed that horses treated with triamcinolone are particularly at higher risk of developing acute laminitis (Hood et al. 1982). However, a causal link between corticosteroids and laminitis in the horse has not been documented (Lawrence et al. 1985). In this report we present a retrospective, uncontrolled study of the clinical use of triamcinolone as triamcinolone acetonide (TMC) in 205 mature horses in a 3-person equine ambulatory clinic and the subsequent incidence of laminitis associated with its use. Materials and methods Case records were retrieved from our clinic of all mature horses treated with TMC (Kenacort-A 10 and Kenacort-A 40)1 between 1 July 1997 and 30 June 2001. Case subject details examined included age, breed, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Equine Veterinary Education Wiley

Clinical use of triamcinolone acetonide in the horse (205 cases) and the incidence of glucocorticoid‐induced laminitis associated with its use

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Publisher
Wiley
Copyright
2004 EVJ Ltd
ISSN
0957-7734
eISSN
2042-3292
DOI
10.1111/j.2042-3292.2004.tb00272.x
Publisher site
See Article on Publisher Site

Abstract

Clinical use of triamcinolone acetonide in the horse (205 cases) and the incidence of glucocorticoid-induced laminitis associated with its use M. J. MCCLUSKEY* AND P. B. KAVENAGH Kavenagh & McCluskey Equine Clinic, 6 Tanner Street, Geelong, Victoria 3219, Australia. Keywords: horse; triamcinolone; laminitis; glucocorticoid Introduction Glucocorticoids have been implicated as a cause of ‘steroidinduced laminitis’ in horses for more than 25 years (Vernimb et al. 1977; Lose 1980; Lawrence et al. 1985; Eustace and Redden 1990; Harkins et al. 1993). It has previously been observed that horses treated with triamcinolone are particularly at higher risk of developing acute laminitis (Hood et al. 1982). However, a causal link between corticosteroids and laminitis in the horse has not been documented (Lawrence et al. 1985). In this report we present a retrospective, uncontrolled study of the clinical use of triamcinolone as triamcinolone acetonide (TMC) in 205 mature horses in a 3-person equine ambulatory clinic and the subsequent incidence of laminitis associated with its use. Materials and methods Case records were retrieved from our clinic of all mature horses treated with TMC (Kenacort-A 10 and Kenacort-A 40)1 between 1 July 1997 and 30 June 2001. Case subject details examined included age, breed,

Journal

Equine Veterinary EducationWiley

Published: Apr 1, 2004

References

  • Pharmacokinetics and metabolic effects of triamcinolone acetonide and their possible relationships to glucocorticoid‐induced laminitis
    French, French; Pollitt, Pollitt; Pass, Pass
  • In vitro evidence for a bacterial pathogenesis of equine laminitis
    Mungall, Mungall; Kyaw‐Tanner, Kyaw‐Tanner; Pollitt, Pollitt
  • Management of heaves
    Robinson, Robinson; Derksen, Derksen; Jackson, Jackson; Peroni, Peroni; Gerber, Gerber
  • Scintigraphic evaluation of digital circulation during the developmental and acute phases of equine laminitis
    Trout, Trout; Hornoff, Hornoff; Linford, Linford; O'Brien, O'Brien

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