Clinical manifestations of cows’ milk allergy in childhood. II. The diagnostic value of skin tests and RAST

Clinical manifestations of cows’ milk allergy in childhood. II. The diagnostic value of skin... Summary In a study of cows’ milk allergy (CMA) in infancy, 135 consecutive challenges were performed on children with a good clinical history of the disorder. Of these, only half of the patients were shown to have the disease. Highly atopic patients responded rapidly to small volumes of milk with acute urticaria, wheezing, stridor and eczema, whereas patients who were relatively non‐atopic developed symptoms of eczema, bronchitis and wheezing over several hours or days. In a statistical evaluation of the diagnostic value of skin tests and RAST it was shown for the extracts used in this investigation, and for the population studied, all patients with SPT 4 had CMA. The results highlight the potential diagnostic value of SPT in the identification of children with some forms of CMA if standardized cows’ milk allergen extracts can be prepared. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical & Experimental Allergy Wiley

Clinical manifestations of cows’ milk allergy in childhood. II. The diagnostic value of skin tests and RAST

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Publisher
Wiley
Copyright
Copyright © 1988 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0954-7894
eISSN
1365-2222
DOI
10.1111/j.1365-2222.1988.tb02898.x
Publisher site
See Article on Publisher Site

Abstract

Summary In a study of cows’ milk allergy (CMA) in infancy, 135 consecutive challenges were performed on children with a good clinical history of the disorder. Of these, only half of the patients were shown to have the disease. Highly atopic patients responded rapidly to small volumes of milk with acute urticaria, wheezing, stridor and eczema, whereas patients who were relatively non‐atopic developed symptoms of eczema, bronchitis and wheezing over several hours or days. In a statistical evaluation of the diagnostic value of skin tests and RAST it was shown for the extracts used in this investigation, and for the population studied, all patients with SPT 4 had CMA. The results highlight the potential diagnostic value of SPT in the identification of children with some forms of CMA if standardized cows’ milk allergen extracts can be prepared.

Journal

Clinical & Experimental AllergyWiley

Published: Sep 1, 1988

References

  • Appraisal of skin tests with food extracts for diagnosis of food hypersensitivity
    Bock, Bock; Lee, Lee; Remigo, Remigo; Holst, Holst; May, May
  • A modern clinical approach to food hypersensitivity
    May, May; Bock, Bock

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