Clinical implications of pretreatment inflammatory biomarkers as independent prognostic indicators in prostate cancer

Clinical implications of pretreatment inflammatory biomarkers as independent prognostic... INTRODUCTIONProstate cancer (PCa) is the most common urological malignant tumors and the second leading cause of cancer‐related death in males after lung cancer. As a result of aging population, altered lifestyle, and increased detection level, PCa continuously increases in China. Most PCa patients are diagnosed at early stage using PSA screening and imaging modalities and can receive promising outcomes through the standard treatment, such as radical prostatectomy or radiotherapy. However, a large amount of PCa patients still present at advanced stage. Because cancer cells have the tendency of distant metastasis, especially bones metastasis, PCa can have detrimental effect on patients’ life. Therefore, efficient indicators are urgently required to predict the progression and prognosis of PCa, thus to assess risk, choose reasonable treatment, and make an appropriate surveillance method. The inflammatory response plays a significant role in the initiation and progression of the tumors, and the predictive value of inflammation markers in tumor prognosis is of interest to academia.Neutrophil‐to‐lymphocyte ratio (NLR) is equal to the absolute value of neutrophils divided by the absolute value of lymphocytes, therefore, a high NLR indicated the increased number of neutrophils or the decreased number of lymphocytes. On the one hand, neutrophilia can promote the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Laboratory Analysis Wiley

Clinical implications of pretreatment inflammatory biomarkers as independent prognostic indicators in prostate cancer

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Wiley Periodicals, Inc.
ISSN
0887-8013
eISSN
1098-2825
D.O.I.
10.1002/jcla.22277
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONProstate cancer (PCa) is the most common urological malignant tumors and the second leading cause of cancer‐related death in males after lung cancer. As a result of aging population, altered lifestyle, and increased detection level, PCa continuously increases in China. Most PCa patients are diagnosed at early stage using PSA screening and imaging modalities and can receive promising outcomes through the standard treatment, such as radical prostatectomy or radiotherapy. However, a large amount of PCa patients still present at advanced stage. Because cancer cells have the tendency of distant metastasis, especially bones metastasis, PCa can have detrimental effect on patients’ life. Therefore, efficient indicators are urgently required to predict the progression and prognosis of PCa, thus to assess risk, choose reasonable treatment, and make an appropriate surveillance method. The inflammatory response plays a significant role in the initiation and progression of the tumors, and the predictive value of inflammation markers in tumor prognosis is of interest to academia.Neutrophil‐to‐lymphocyte ratio (NLR) is equal to the absolute value of neutrophils divided by the absolute value of lymphocytes, therefore, a high NLR indicated the increased number of neutrophils or the decreased number of lymphocytes. On the one hand, neutrophilia can promote the

Journal

Journal of Clinical Laboratory AnalysisWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ;

References

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