IntroductionCommunity surveys suggest that chronic constipation is the most common gastrointestinal symptom of diabetes mellitus (DM); however, the pathogenesis remains poorly defined. There are a number of potential risk factors for constipation in patients with DM, including diabetic neuropathy, acute and chronic glycemic control, psychological distress, and lifestyle factors. Additionally, with progress in the treatment for DM, new therapeutic drugs bring with them factors that may affect the function of the digestive tract. In particular, dipeptidyl peptidase‐4 (DDP4) inhibitor and glucagon‐like peptide‐1 (GLP‐1) receptor agonists are thought to have a significant influence on digestive symptoms. However, few studies have examined factors associated with symptoms of constipation in current clinical practice. The current study was a multicenter study to determine clinical risk factors associated with symptoms of constipation in patients with DM.MethodsEthical considerationsThis multicenter study was approved by the Ethics Committees of Saiseikai Yokohama‐shi Nanbu Hospital on June 1, 2017, and by each participating center, and is registered with the University Hospital Medical Information Network in Japan (UMIN000022994). Informed consent was obtained from all participants before filling in the questionnaire.Participants and survey methodThe study was performed at three hospitals (Saiseikai Yokohama‐shi Nanbu Hospital, Yokohama Sakae Kyosai Hospital, and Machida Municipal
Journal of Gastroenterology and Hepatology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ;
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