INTRODUCTIONCrohn's disease (CD) and ulcerative colitis (UC) are chronic intestinal disorders that together form the complex of inflammatory bowel disease (IBD). The pathogenesis of these diseases involves the inappropriate activation of the mucosal immune system, which is triggered by the intestinal microbiota in genetically predisposed individuals. Mutations in the nucleotide‐binding oligomerization domain‐containing protein 2 (NOD2) gene encoding for NOD2 have been shown to be a major risk factor in the development of CD. In addition, environmental factors, such as vitamin D deficiency, have been found to play a role in the pathogenesis of IBD. Vitamin D is commonly known to be an important regulator of calcium and phosphate metabolism and is therefore essential for bone health. However, there is mounting evidence that vitamin D also plays an important role as a regulator of the innate and adaptive immune system. In a murine colitis model the application of calcitriol was associated with reduced mucosal injury. The prevalence of vitamin D deficiency is high in patients with IBD. However, it is still not clear whether vitamin D substitution has a beneficial effect on the course of the disease. In a prospective study infliximab treatment was associated with positive effects on bone
Journal of Digestive Diseases – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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