P470 A low‐carbohydrate diet is an effective treatment for prediabetesDJ UNWIN1,2 and D Cavan31Norwood Surgery, Southport, UK, 2Royal College of General Practitioners, London, UK, 3Royal College of Physicians, London, UKAims: The diabetes prevention programme showed that 14.8% of participants regressed to normal glucose metabolism on a low‐fat diet. We assessed the effectiveness of advising a low‐carbohydrate diet to people with prediabetes attending a single, general practice.Methods: Dietary advice that focused on carbohydrate restriction was provided to 43 people [23 male, mean (SD) age 64.4 (11.5) years] with prediabetes (defined as having an HbA1c between 42 and 48 mmol/mol) attending a single, general practice. They were provided with written information about carbohydrate restriction and offered bimonthly follow‐up for a mean 22 (range 5 to 54) months.Results: Mean HbA1c fell from 44.1 (2.2) to 38.9 (2.7) mmol/mol (p < 0.0001), body weight reduced from 90.6 (15.4) to 81.5 (14.5) kg (p < 0.0001) and body mass index from 33.7 (7.1) to 30.1 (6.7) kg/m2 (p < 0.0001). Significant reductions were also seen in serum gamma glutamyltransferase (GGT), total cholesterol:high‐density lipoprotein (HDL) ratio, triglycerides and systolic and diastolic blood pressure. There was a significant increase in HDL‐cholesterol. Forty (93%) individuals regressed to an HbA1c below 42%, indicating return to normal glucose metabolism. Three
Diabetic Medicine – Wiley
Published: Jan 1, 2018
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