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Circulating Endocannabinoid Concentrations and Sexual Arousal in Women

Circulating Endocannabinoid Concentrations and Sexual Arousal in Women ABSTRACT Introduction. Several lines of evidence point to the potential role of the endocannabinoid system in female sexual functioning. These include results from studies describing the subjective effects of exogenous cannabinoids on sexual functioning in humans and the observable effects of exogenous cannabinoids on sexual functioning in other species, as well as results from studies investigating the location of cannabinoid receptors in the brain and periphery, and the effects of cannabinoid receptor activation on neurotransmitters implicated in sexual functioning. While these lines of research suggest a role for the endocannabinoid system in female sexual functioning, no studies investigating the relationship between concentrations of endogenous cannabinoids (i.e., arachidonoylethanolamide (AEA) and 2‐arachidonoylglycerol (2‐AG)) and sexual functioning have been conducted in any species. Aim. To measure circulating endocannabinoid concentrations in relation to subjective and physiological indices of sexual arousal in women (N = 21). Methods. Serum endocannabinoid (AEA and 2‐AG) concentrations were measured immediately prior to, and immediately following, viewing of neutral (control) and erotic (experimental) film stimuli in a repeated measures design. Physiological sexual arousal was measured via vaginal photoplethysmography. Subjective sexual arousal was measured both continuously and noncontinuously. Pearson's correlations were used to investigate the relationships between endocannabinoid concentrations and sexual arousal. Main Outcome Measures. Changes in AEA and 2‐AG concentrations from pre‐ to post‐film and in relation to physiological and subjective indices of sexual arousal. Results. Results revealed a significant relationship between endocannabinoid concentrations and female sexual arousal, whereby increases in both physiological and subjective indices of sexual arousal were significantly associated with decreases in AEA, and increases in subjective indices of sexual arousal were significantly associated with decreases in 2‐AG. Conclusions. These findings support the hypothesis that the endocannabinoid system is involved in female sexual functioning, with implications for furthering understanding of the biological mechanisms underlying female sexual functioning. Klein C, Hill MN, Chang SCH, Hillard CJ, and Gorzalka BB. Circulating endocannabinoid concentrations and sexual arousal in women. J Sex Med 2012;9:1588–1601. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Sexual Medicine Wiley

Circulating Endocannabinoid Concentrations and Sexual Arousal in Women

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Publisher
Wiley
Copyright
© 2012 International Society for Sexual Medicine
ISSN
1743-6095
eISSN
1743-6109
DOI
10.1111/j.1743-6109.2012.02708.x
pmid
22462722
Publisher site
See Article on Publisher Site

Abstract

ABSTRACT Introduction. Several lines of evidence point to the potential role of the endocannabinoid system in female sexual functioning. These include results from studies describing the subjective effects of exogenous cannabinoids on sexual functioning in humans and the observable effects of exogenous cannabinoids on sexual functioning in other species, as well as results from studies investigating the location of cannabinoid receptors in the brain and periphery, and the effects of cannabinoid receptor activation on neurotransmitters implicated in sexual functioning. While these lines of research suggest a role for the endocannabinoid system in female sexual functioning, no studies investigating the relationship between concentrations of endogenous cannabinoids (i.e., arachidonoylethanolamide (AEA) and 2‐arachidonoylglycerol (2‐AG)) and sexual functioning have been conducted in any species. Aim. To measure circulating endocannabinoid concentrations in relation to subjective and physiological indices of sexual arousal in women (N = 21). Methods. Serum endocannabinoid (AEA and 2‐AG) concentrations were measured immediately prior to, and immediately following, viewing of neutral (control) and erotic (experimental) film stimuli in a repeated measures design. Physiological sexual arousal was measured via vaginal photoplethysmography. Subjective sexual arousal was measured both continuously and noncontinuously. Pearson's correlations were used to investigate the relationships between endocannabinoid concentrations and sexual arousal. Main Outcome Measures. Changes in AEA and 2‐AG concentrations from pre‐ to post‐film and in relation to physiological and subjective indices of sexual arousal. Results. Results revealed a significant relationship between endocannabinoid concentrations and female sexual arousal, whereby increases in both physiological and subjective indices of sexual arousal were significantly associated with decreases in AEA, and increases in subjective indices of sexual arousal were significantly associated with decreases in 2‐AG. Conclusions. These findings support the hypothesis that the endocannabinoid system is involved in female sexual functioning, with implications for furthering understanding of the biological mechanisms underlying female sexual functioning. Klein C, Hill MN, Chang SCH, Hillard CJ, and Gorzalka BB. Circulating endocannabinoid concentrations and sexual arousal in women. J Sex Med 2012;9:1588–1601.

Journal

The Journal of Sexual Medicine – Wiley

Published: Jun 1, 2012

References

  • Cannabinoids, reproduction and sexual behavior
    Gorzalka, Gorzalka; Hill, Hill
  • Male–female differences in the effects of endocannabinoids on sexual behavior and gonadal hormone function
    Gorzalka, Gorzalka; Hill, Hill; Chang, Chang
  • Marijuana and sex
    Goode, Goode
  • Marijuana and sexual activity
    Koff, Koff
  • An attitude survey of the effects of marijuana on sexual enjoyment
    Dawley, Dawley; Winstead, Winstead; Baxter, Baxter; Gay, Gay
  • Effects of regular marijuana use on sexual performance
    Halikas, Halikas; Weller, Weller; Morse, Morse
  • The association of sexual dysfunction and substance use among a community epidemiological sample
    Johnson, Johnson; Phelps, Phelps; Cottler, Cottler
  • Marihuana and sex: A critical survey
    Abel, Abel
  • Cannabis: Pharmacology and toxicology in animals and humans
    Adams, Adams; Martin, Martin
  • Cannabis effects and dependency concerns in long‐term frequent users: A missing piece of the public health puzzle
    Hathaway, Hathaway
  • Δ9‐Tetrahydrocannabinol enhancement of lordosis behaviour in estrogen treated female rats
    Gordon, Gordon; Bromley, Bromley; Gorski, Gorski; Zimmermann, Zimmermann
  • Δ9‐tetrahydrocannabinol stimulates receptive and proceptive sexual behaviors in female hamsters
    Turley, Turley; Floody, Floody
  • Progesterone receptor and dopamine receptors are required in Δ9‐tetrahydrocannabinol modulation of sexual receptivity in female rats
    Mani, Mani; Mitchell, Mitchell; O'Malley, O'Malley
  • Inhibitory effects of the cannabinoid agonist HU 210 on rat sexual behaviour
    Ferrari, Ferrari; Ottani, Ottani; Giuliani, Giuliani
  • Acute cannabinoid administration attenuates female socio‐sexual motivation
    López, López; Zappia, Zappia; Cushman, Cushman; Chadwick, Chadwick
  • Cannabinoid receptor antagonism increases female sexual motivation
    López, López; Webb, Webb; Nash, Nash
  • Physiology of women's sexual function: Basic knowledge and new findings
    Salonia, Salonia; Giraldi, Giraldi; Chivers, Chivers; Georgiadis, Georgiadis; Levin, Levin; Maravilla, Maravilla; McCarthy, McCarthy
  • Characterization and localization of cannabinoid receptors in rat brain: A quantitative autoradiographic study
    Herkenham, Herkenham; Lynn, Lynn; Johnson, Johnson; Melvin, Melvin; de Costa, de Costa; Rice, Rice
  • Cannabinoid receptor localization in brain
    Herkenham, Herkenham; Lynn, Lynn; Little, Little; Johnson, Johnson; Melvin, Melvin; de Costa, de Costa; Rice, Rice
  • Cannabinoid receptors in rat brain areas: Sexual differences, fluctuations during estrous cycle and changes after gonadectomy and sex steroid replacement
    Rodriguez de Fonseca, Rodriguez de Fonseca; Cabeira, Cabeira; Ramos, Ramos; Martin, Martin; Fernandez‐Ruiz, Fernandez‐Ruiz
  • Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
    Tsou, Tsou; Brown, Brown; Sanudo‐Pena, Sanudo‐Pena; Mackie, Mackie; Walker, Walker
  • Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
    Geliegue, Geliegue; Mary, Mary; Marchand, Marchand; Dussossoy, Dussossoy; Carriere, Carriere; Carayon, Carayon; BouaBoula, BouaBoula; Shire, Shire; Le Fur, Le Fur; Casellas, Casellas
  • Effect of Δ9‐tetrahydrocannabinol on the synthesis of dopamine and norepinephrine in mouse brain synaptosomes
    Bloom, Bloom
  • The endogenous cannabinoid receptor ligand, anandamide, inhibits the motor behaviour: Role of nigrostriatal dopaminergic neurons
    Romero, Romero; Garcia, Garcia; Cebeira, Cebeira; Zadrozny, Zadrozny; Fernandez‐Ruiz, Fernandez‐Ruiz; Ramos, Ramos
  • Modulation of transmitter release via presynaptic cannabinoid receptors
    Schlicker, Schlicker; Kathmann, Kathmann
  • Serotonin receptor subtypes and sexual behaviour
    Gorzalka, Gorzalka; Mendelson, Mendelson; Watson, Watson
  • Dopamine and sexual behavior
    Melis, Melis; Argiolas, Argiolas
  • Sexual psychophysiology and effects of sildenafil citrate in oestrogenised women with acquired genital arousal disorder and impaired orgasm: A randomised trial
    Basson, Basson; Brotto, Brotto
  • Female sexual arousal disorder subtypes: Differentiation via laboratory‐induced hyperventilation
    Brotto, Brotto; Klein, Klein; Gorzalka, Gorzalka
  • A vaginal plethysmograph system
    Sintchak, Sintchak; Geer, Geer
  • Sexual arousal in women: The development of a measurement device for vaginal blood volume
    Geer, Geer; Morokoff, Morokoff; Greenwood, Greenwood
  • A psychophysiological exploration of sexual arousal patterns in females and males
    Heiman, Heiman
  • Assessment of female sexual arousal: Response specificity and construct validity
    Laan, Laan; Everaerd, Everaerd; Evers, Evers
  • Physiologic measures of sexual function in women: A review
    Woodward, Woodward; Diamond, Diamond
  • Psychophysiological assessment in premenopausal sexual arousal disorder
    Brotto, Brotto; Basson, Basson; Gorzalka, Gorzalka
  • Genital and subjective sexual arousal in postmenopausal women: Influence of laboratory‐induced hyperventilation
    Brotto, Brotto; Gorzalka, Gorzalka
  • Affective and physiological sexual response patterns: The effects of instructions on sexually functional and dysfunctional men
    Heiman, Heiman; Rowland, Rowland
  • Female sexual response patterns: Interactions of physiological, affective, and contextual cues
    Heiman, Heiman
  • Affective and physiological dimensions of male sexual response to erotica and fantasy
    Heiman, Heiman; Hatch, Hatch
  • The relationship between women's subjective and physiological sexual arousal
    Rellini, Rellini; McCall, McCall; Randall, Randall; Meston, Meston
  • The sensitivity of continuous laboratory measures of physiological and subjective sexual arousal for diagnosing women with sexual arousal disorder
    Meston, Meston; Rellini, Rellini; McCall, McCall
  • The DSFI: A multidimensional measure of sexual functioning
    Derogatis, Derogatis; Melisaratos, Melisaratos
  • A psychological profile of the sexual dysfunctions
    Derogatis, Derogatis; Meyer, Meyer
  • The Female Sexual Function Index (FSFI): A multidimensional self‐report instrument for the assessment of female sexual function
    Rosen, Rosen; Brown, Brown; Heiman, Heiman; Leiblum, Leiblum; Meston, Meston; Shabsigh, Shabsigh; Ferguson, Ferguson; D'Agostino, D'Agostino
  • Sexual disorders in subjects treated for mood and anxiety diseases
    Bossini, Bossini; Fagiolini, Fagiolini; Valdagno, Valdagno; Polizzotto, Polizzotto; Castrogiovanni, Castrogiovanni
  • Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic–pituitary–adrenal axis
    Hill, Hill; McLaughlin, McLaughlin; Morrish, Morrish; Viau, Viau; Floresco, Floresco; Hillard, Hillard; Gorzalka, Gorzalka
  • Impairments in endocannabinoid signalling and depressive illness
    Hill, Hill; Gorzalka, Gorzalka
  • Serum endocannabinoid content is altered in females with depressive disorders: A preliminary report
    Hill, Hill; Miller, Miller; Ho, Ho; Gorzalka, Gorzalka; Hillard, Hillard
  • An inventory for measuring clinical anxiety: Psychometric properties
    Beck, Beck; Epstein, Epstein; Brown, Brown; Steer, Steer
  • The postmortal accumulation of brain N‐arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity
    Patel, Patel; Carrier, Carrier; Ho, Ho; Rademacher, Rademacher; Cunningham, Cunningham; Reddy, Reddy; Falck, Falck; Cravatt, Cravatt; Hillard, Hillard
  • Circulating endocannabinoids and N‐acyl ethanolamines are differentially regulated in major depression and following exposure to social stress
    Hill, Hill; Miller, Miller; Carrier, Carrier; Gorzalka, Gorzalka; Hillard, Hillard
  • Inhibition of subjective and physiological sexual arousal in women by clonidine
    Meston, Meston; Gorzalka, Gorzalka; Wright, Wright
  • Differential effects of sympathetic activation on sexual arousal in sexually dysfunctional and functional women
    Meston, Meston; Gorzalka, Gorzalka
  • Plasma noradrenaline and dopamine‐beta‐hydroxylase during human sexual activity
    Wiedeking, Wiedeking; Ziegler, Ziegler; Lake, Lake
  • Cannabinoid receptors are localized to noradrenergic axon terminals in the rat frontal cortex
    Oropeza, Oropeza; Mackie, Mackie; Van Bockstaele, Van Bockstaele
  • Effects of alcohol on sexual arousal in women
    Wilson, Wilson; Lawson, Lawson
  • Effect of anaesthesia and cardiopulmonary bypass on blood endocannabinoid concentrations during cardiac surgery
    Weiss, Weiss; Beiras‐Fernandez, Beiras‐Fernandez; Hauer, Hauer; Hornuss, Hornuss; Sodian, Sodian; Kreth, Kreth; Briegel, Briegel; Schelling, Schelling
  • Endogenous cannabinoid signalling is essential for stress adaptation
    Hill, Hill; McLaughlin, McLaughlin; Bingham, Bingham; Shrestha, Shrestha; Lee, Lee; Gray, Gray; Hillard, Hillard; Gorzalka, Gorzalka; Viau, Viau
  • Are the complexities of women's sexual function reflected in the new consensus definitions of dysfunction?
    Basson, Basson
  • A model of women's sexual arousal
    Basson, Basson
  • Report of the international consensus development conference on female sexual dysfunction: Definitions and classifications
    Basson, Basson; Berman, Berman; Burnett, Burnett; Derogatis, Derogatis; Ferguson, Ferguson; Fourcroy, Fourcroy; Goldstein, Goldstein; Graziottin, Graziottin; Heiman, Heiman; Laan, Laan; Leiblum, Leiblum; Padma‐Nathan, Padma‐Nathan; Rosen, Rosen; Segraves, Segraves; Segraves, Segraves; Shabsigh, Shabsigh; Sipski, Sipski; Wagner, Wagner; Whipple, Whipple
  • Definitions of women's sexual dysfunction reconsidered: Advocating expansion and revision
    Basson, Basson; Leiblum, Leiblum; Brotto, Brotto; Derogatis, Derogatis; Fourcroy, Fourcroy; Fugl‐Meyer, Fugl‐Meyer; Graziottin, Graziottin; Heiman, Heiman; Laan, Laan; Meston, Meston; Schover, Schover; van Linkveld, van Linkveld; Schultz, Schultz
  • Regulation of endocannabinoid signaling by stress: Implications for stress‐related affective disorders
    Gorzalka, Gorzalka; Hill, Hill; Hillard, Hillard