Access the full text.
Sign up today, get DeepDyve free for 14 days.
C. Steidl, Tang Lee, Sohrab Shah, Pedro Farinha, G. Han, Tarun Nayar, Allen Delaney, Steven Jones, J. Iqbal, D. Weisenburger, M. Bast, A. Rosenwald, H. Muller-Hermelink, L. Rimsza, E. Campo, J. Delabie, R. Braziel, J. Cook, R. Tubbs, E. Jaffe, G. Lenz, J. Connors, L. Staudt, W. Chan, R. Gascoyne (2010)
Tumor-associated macrophages and survival in classic Hodgkin's lymphoma.The New England journal of medicine, 362 10
H. Kimura, M. Morita, Yumi Yabuta, K. Kuzushima, Koji Kato, Seiji Kojima, T. Matsuyama, T. Morishima (1999)
Quantitative Analysis of Epstein-Barr Virus Load by Using a Real-Time PCR AssayJournal of Clinical Microbiology, 37
A. Schram, N. Berliner (2015)
How I treat hemophagocytic lymphohistiocytosis in the adult patient.Blood, 125 19
Sanghui Park, Y. Ko (2014)
Epstein–Barr virus‐associated T/natural killer‐cell lymphoproliferative disordersThe Journal of Dermatology, 41
H. Kimura, Yoshinori Ito, Shinji Kawabe, K. Gotoh, Yoshiyuki Takahashi, S. Kojima, T. Naoe, S. Esaki, A. Kikuta, A. Sawada, K. Kawa, K. Ohshima, S. Nakamura (2012)
EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases.Blood, 119 3
A. Alexopoulos, I. Thanopoulou, M. Dakoutrou, E. Georgiadou, G. Chrousos, T. Kakourou (2018)
Atenolol treatment for severe Infantile Hemangiomas: a single‐centre prospective studyJournal of the European Academy of Dermatology and Venereology, 32
J. Cohen, E. Jaffe, J. Dale, S. Pittaluga, H. Heslop, C. Rooney, S. Gottschalk, C. Bollard, V. Rao, A. Marques, P. Burbelo, Siu-Ping Turk, R. Fulton, A. Wayne, R. Little, M. Cairo, N. El-Mallawany, D. Fowler, C. Sportés, M. Bishop, W. Wilson, S. Straus (2011)
Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States.Blood, 117 22
M. Yoshimori, K. Imadome, Honami Komatsu, Ludan Wang, Y. Saitoh, S. Yamaoka, T. Fukuda, M. Kurata, T. Koyama, N. Shimizu, S. Fujiwara, O. Miura, A. Arai (2014)
CD137 Expression Is Induced by Epstein-Barr Virus Infection through LMP1 in T or NK Cells and Mediates Survival Promoting SignalsPLoS ONE, 9
Lindsay Eminger, L. Hall, Kathleen Hesterman, W. Heymann (2015)
Epstein-Barr virus: dermatologic associations and implications: part II. Associated lymphoproliferative disorders and solid tumors.Journal of the American Academy of Dermatology, 72 1
Dear Editor,Patients with chronic active Epstein–Barr virus (EBV) infections (CAEBV) present with cutaneous manifestations including hydroa vacciniforme‐like eruptions. Haemophagocytic lymphohistiocytosis (HLH), a fatal complication, can occur in severe cases of CAEBV. We retrieved 25 cases of CAEBV treated in our hospital and histopathologically characterized the skin lesions of three of those cases, including one case with haemophagocytosis. This is a novel report of CAEBV with haemophagocytosis in the skin.Patient No. 1: A 29‐year‐old male who had been suffering from multiple indurated erythematous plaques on his hands and lower limbs for 15 months (Fig. a, b). Laboratory investigations revealed a decreased number of platelets: 4.3 × 104/μL (normal: 13–30 × 104/μL). The titres of anti‐EBV antibodies were as follows: viral capsid antigen (VCA) IgG ×640; VCA IgM less than ×10; EBV nuclear antigen ×80. The EBV genome load in peripheral blood (PB) was 7.7 × 105 copies/μg DNA. His EBV‐infected cells were CD56‐positive, and the diagnosis of CAEBV was made according to Kimura et al. Histopathological examination showed atypical lymphoid cells in the dermis and subcutaneous adipose tissue (Fig. c,d). Infiltrates consisted of atypical lymphoid cells (Fig. e). Immunohistochemical examination showed positive reactions for CD3, CD56 (Fig. f), TIA‐1 (Fig. g) and granzyme B. Atypical lymphoid cells were positive for EBV‐encoded small RNA
Journal of the European Academy of Dermatology & Venereology – Wiley
Published: Jan 1, 2018
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.