BY V. VAN HEYNINGEN,* M. BOBROW, W. F. BODMER Genetics Laboratory, Department of Biochemistry, University of Oxford S. E. GARDINER, S. POVEY AND D. A. HOPKINSON MRC Human Biochemical Genetics Unit, The Galton Laboratory, University College London Family studies on human mitochondrial malate dehydrogenase (EC. 126.96.36.199) MOR-M (Davidson & Cortner, 1967) have shown that i t is autosomally determined but have not so far suggested on which chromosome the structural gene is located. Somatic cell genetic analysis of this enzyme has been hampered by the fact that the electrophoretic mobilities of the most common human form and the usual mouse form are almost identical. I n order to overcome this problem we used an immunochemical method to distinguish human and mouse MOR-M. (van Heyningen, Craig & Bodmer 1973).The initial results (J.Rowley and S. Craig,unpublished) indicated that human MOR-M might be segregating with chromosome 7. Other work has suggested that the structural gene for mannosephosphate isomerase, (EC .188.8.131.52) MPI, is on chromosome 7 (McMorris et al. 1973) and one of the loci for pyruvate kinase, (EC. 184.108.40.206) PK-3, has also been assigned to this chromosome by synteny with MPI (Shows, 1972). We present here evidence from interspecific (human-mouse) somatic
Annals of Human Genetics – Wiley
Published: Jan 1, 1975
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