Cholinergic modulation of responses to single tones produces tone‐specific receptive field alterations in cat auditory cortex

Cholinergic modulation of responses to single tones produces tone‐specific receptive field... Acetylcholine (ACh), acting via muscarinic receptors, is known to modulate neuronal responsiveness in primary sensory neocrotex. The administration of ACh to cortical neurons facilitates or suppresses responses to sensory stimuli, and these effects can endure well beyond the period of ACh application. In the present study, we sought to determine whether ACh produces a general change in sensory information processing, or it can specifically alter the processing of sensory stimuli with which it was “paired.” To answer this question, we restricted acoustic stimulation in the presensce of ACh to a single frequency, and determined single neuron frequency receptive fields in primary auditory cortex before and after this pairing. During its adminidstration, ACh produced mostly facilitatory effects on spontaneous activity and on responses to the single frequency tone. Examination of frequency receptive fields after ACh administration revealed receptive field modifications in 56% of the cells. In half of these cases, the receptive field alterations were highly specific to the frequency of the tone previously paired with ACh. Thus ACh can produce stimulus‐specific modulation of auditory information processing. An additional and unexpected finding was that the type of modulation during ACh administration did not predict the type of receptive field modulation observed after ACh administration; this may be related to the physiological “cortext” of the same stimulus in two different conditions. The implications of these findings for learning‐induced plasticity in the auditory cortex is discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Synapse Wiley

Cholinergic modulation of responses to single tones produces tone‐specific receptive field alterations in cat auditory cortex

Synapse, Volume 6 (2) – Jan 1, 1990

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Publisher
Wiley
Copyright
Copyright © 1990 Wiley‐Liss, Inc.
ISSN
0887-4476
eISSN
1098-2396
DOI
10.1002/syn.890060204
pmid
2237776
Publisher site
See Article on Publisher Site

Abstract

Acetylcholine (ACh), acting via muscarinic receptors, is known to modulate neuronal responsiveness in primary sensory neocrotex. The administration of ACh to cortical neurons facilitates or suppresses responses to sensory stimuli, and these effects can endure well beyond the period of ACh application. In the present study, we sought to determine whether ACh produces a general change in sensory information processing, or it can specifically alter the processing of sensory stimuli with which it was “paired.” To answer this question, we restricted acoustic stimulation in the presensce of ACh to a single frequency, and determined single neuron frequency receptive fields in primary auditory cortex before and after this pairing. During its adminidstration, ACh produced mostly facilitatory effects on spontaneous activity and on responses to the single frequency tone. Examination of frequency receptive fields after ACh administration revealed receptive field modifications in 56% of the cells. In half of these cases, the receptive field alterations were highly specific to the frequency of the tone previously paired with ACh. Thus ACh can produce stimulus‐specific modulation of auditory information processing. An additional and unexpected finding was that the type of modulation during ACh administration did not predict the type of receptive field modulation observed after ACh administration; this may be related to the physiological “cortext” of the same stimulus in two different conditions. The implications of these findings for learning‐induced plasticity in the auditory cortex is discussed.

Journal

SynapseWiley

Published: Jan 1, 1990

References

  • Dependence of auditory cortex evoked unit activity on interstimulus interval in the cat
    Hocherman, Hocherman; Gilat, Gilat
  • The mechanism of excitation by acetylcholine in the cerebral cortex
    Krnjevic, Krnjevic; Pumain, Pumain; Renaud, Renaud
  • An iontophoretic study of single somatosensory neurons in rat granular cortex serving the limbs: A laminar analysis of glutamate and acetylcholine effects on receptive‐field properties
    Lamour, Lamour; Dutar, Dutar; Jobert, Jobert; Dykes, Dykes
  • Mechanism of action of acetylcholine in the guinea‐pig cerebral cortex in vitro
    McCormick, McCormick; Prince, Prince
  • Muscarinic agonists modulate spontaneous and evoked unit discharge in auditory cortex of cat
    McKenna, McKenna; Ashe, Ashe; Hui, Hui; Weinberger, Weinberger
  • The effects of acetylcholine on response properties of cat somatosensory cortical neurons
    Metherate, Metherate; Tremblay, Tremblay; Dykes, Dykes
  • A functional role of cholinergic innervation to neurons in the cat visual cortex
    Sato, Sato; Hata, Hata; Masui, Masui; Tsumoto, Tsumoto
  • The pharmacology of memory: a neurobiological perspective
    Squire, Squire; Davis, Davis
  • Single cell responses striate cortex of kittens deprived of vision in one eye
    Wiesel, Wiesel; Hubel, Hubel

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