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CHOLINE UPTAKE BY CHOLINERGIC NEURON CELL SOMAS

CHOLINE UPTAKE BY CHOLINERGIC NEURON CELL SOMAS The cellular compartments of ciliary ganglia take up choline by a single, saturable process with Km=7.1 × 10−5 M and Vmax= 4.66 pmol/min per ganglion: Denervation of the ganglia and the resultant degeneration of nerve terminals caused no significant decrease of the rate of accumulation of choline by the ganglia. This indicates that the measured uptake is by the postganglionic ncurons and nonneural elements (NNE: glial and connective tissue cells) in the ganglia. This uptakc is not dependent on metabolic energy and is not affectcd by lowcring Na+ or raising K+ concentrations in the incubating mcdia but is depressed in the presence of ouabain and hemicholinium‐3. The presence or Na+‐dependent. rapidly saturable uptake in the preganglionic nerve terminals which is not detectablc kinetically is, however, inferred from a decrease in ACh synthesis in dcncrvatcd prcparations and a similar decrcasc in intact ganglia incubated in low Na+ solution. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

CHOLINE UPTAKE BY CHOLINERGIC NEURON CELL SOMAS

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References (20)

Publisher
Wiley
Copyright
Copyright © 1976 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3042
eISSN
1471-4159
DOI
10.1111/j.1471-4159.1976.tb06995.x
Publisher site
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Abstract

The cellular compartments of ciliary ganglia take up choline by a single, saturable process with Km=7.1 × 10−5 M and Vmax= 4.66 pmol/min per ganglion: Denervation of the ganglia and the resultant degeneration of nerve terminals caused no significant decrease of the rate of accumulation of choline by the ganglia. This indicates that the measured uptake is by the postganglionic ncurons and nonneural elements (NNE: glial and connective tissue cells) in the ganglia. This uptakc is not dependent on metabolic energy and is not affectcd by lowcring Na+ or raising K+ concentrations in the incubating mcdia but is depressed in the presence of ouabain and hemicholinium‐3. The presence or Na+‐dependent. rapidly saturable uptake in the preganglionic nerve terminals which is not detectablc kinetically is, however, inferred from a decrease in ACh synthesis in dcncrvatcd prcparations and a similar decrcasc in intact ganglia incubated in low Na+ solution.

Journal

Journal of Neurochemistry – Wiley

Published: Jun 1, 1976

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