Choline High‐Affinity Uptake and Metabolism and Choline Acetyltransferase Activity in the Striatum of Rats Chronically Treated with Neuroleptics

Choline High‐Affinity Uptake and Metabolism and Choline Acetyltransferase Activity in the... : High‐affinity uptake of choline and choline acetyltransferase activity (ChAT) were measured in the striatum of rats treated for 45–60 days with haloperidol (1 mg/kg per os) and pimozide (1 mg/kg per os) daily and with fluspirilene (1 mg/kg i.m.) twice a week. Haloperidol and fluspirilene caused a 29%, and pimozide a 38%, increase in high‐affinity uptake of choline. They also caused a significant decrease in ChAT activity: haloperidol, 20%; pimozide, 27%; and fluspirilene, 42%. In rats treated with fluspirilene for 65–80 days the metabolism of (3H)choline taken up by striatal synaptosomes was investigated. A 33% increase in total radioactivity, a significant increase in labelled acetylcholine (ACh), a relative decrease in labelled choline, and no change in labelled phosphorylcholine and betaine were found. It is concluded that the increase in high‐affinity choline uptake caused by chronic administration of neuroleptic drugs is associated with a parallel increase in choline utilization for ACh formation. On the other hand, the decrease in ChAT activity does not appear to influence ACh formation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

Choline High‐Affinity Uptake and Metabolism and Choline Acetyltransferase Activity in the Striatum of Rats Chronically Treated with Neuroleptics

Journal of Neurochemistry, Volume 35 (3) – Sep 1, 1980

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Publisher
Wiley
Copyright
Copyright © 1980 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3042
eISSN
1471-4159
D.O.I.
10.1111/j.1471-4159.1980.tb03698.x
Publisher site
See Article on Publisher Site

Abstract

: High‐affinity uptake of choline and choline acetyltransferase activity (ChAT) were measured in the striatum of rats treated for 45–60 days with haloperidol (1 mg/kg per os) and pimozide (1 mg/kg per os) daily and with fluspirilene (1 mg/kg i.m.) twice a week. Haloperidol and fluspirilene caused a 29%, and pimozide a 38%, increase in high‐affinity uptake of choline. They also caused a significant decrease in ChAT activity: haloperidol, 20%; pimozide, 27%; and fluspirilene, 42%. In rats treated with fluspirilene for 65–80 days the metabolism of (3H)choline taken up by striatal synaptosomes was investigated. A 33% increase in total radioactivity, a significant increase in labelled acetylcholine (ACh), a relative decrease in labelled choline, and no change in labelled phosphorylcholine and betaine were found. It is concluded that the increase in high‐affinity choline uptake caused by chronic administration of neuroleptic drugs is associated with a parallel increase in choline utilization for ACh formation. On the other hand, the decrease in ChAT activity does not appear to influence ACh formation.

Journal

Journal of NeurochemistryWiley

Published: Sep 1, 1980

References

  • Choline acetyltransferase and the high affinity uptake of choline in corpus striatum of reserpinised rats
    Burgess, Burgess; Atterwill, Atterwill; Prince, Prince
  • Caudate nucleus neurons: Correlation of the effects of substantia nigra stimulation with iontophoretic dopamine
    Connor, Connor
  • A rapid radiochemical method for the determination of choline acetyltransferase
    Fonnum, Fonnum
  • Effects of chronic treatment with neuroleptics on striatal acetylcholine concentration
    Sethy, Sethy
  • Sodium dependent high affinity choline uptake: A regulatory step in the synthesis of acetylcholine
    Simon, Simon; Atweh, Atweh; Kuhar, Kuhar

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