Chemical Composition and In vitro Anthelmintic Activity of Extracts of Tagetes patula Against a Multidrug‐Resistant Isolate of Haemonchus contortus

Chemical Composition and In vitro Anthelmintic Activity of Extracts of Tagetes patula Against a... Sheep breeding has suffered economic losses due to parasitism by gastrointestinal nematodes, particularly Haemonchus contortus. The use of natural products, specifically Tagetes patula, has been suggested as an alternative method of combatting this issue. Chemical analyses of the extracts of this species described in the literature report the presence of important classes of secondary metabolites such as thiophenes, flavonoids, alkaloids, and benzofurans, some of which were identified and isolated in this study. The aim of this work was to test the effect of the essential oil (EO) and the ethanolic extract of the aerial parts (TpEtOH) of T. patula on eggs and larvae of H. contortus, through an egg hatch test (EHT) and a larval development test (LDT). In the EHT, the EO showed 100% inhibition at 0.75 mg mL−1 (LC50 = 0.0780 mg mL−1), and the TpEtOH showed 100% inhibition at 100 mg mL−1 (LC50 = 12.8 mg mL−1). In the LDT, the EO showed 100% inhibition at 0.375 mg mL−1 (LC50 = 0.0400 mg mL−1), and the TpEtOH showed 100% inhibition at 1.56 mg mL−1 (LC50 = 0.340 mg mL−1). Compared to available literature data, the results presented here suggest that the crude extracts of T. patula have substantial potential for controlling this nematode by interrupting its life cycle and/or preventing it from reaching the infective stage. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemistry & Biodiversity Wiley

Chemical Composition and In vitro Anthelmintic Activity of Extracts of Tagetes patula Against a Multidrug‐Resistant Isolate of Haemonchus contortus

Loading next page...
 
/lp/wiley/chemical-composition-and-in-vitro-anthelmintic-activity-of-extracts-of-Bs0UgPHWcP
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley‐VHCA AG, Zurich, Switzerland
ISSN
1612-1872
eISSN
1612-1880
D.O.I.
10.1002/cbdv.201700507
Publisher site
See Article on Publisher Site

Abstract

Sheep breeding has suffered economic losses due to parasitism by gastrointestinal nematodes, particularly Haemonchus contortus. The use of natural products, specifically Tagetes patula, has been suggested as an alternative method of combatting this issue. Chemical analyses of the extracts of this species described in the literature report the presence of important classes of secondary metabolites such as thiophenes, flavonoids, alkaloids, and benzofurans, some of which were identified and isolated in this study. The aim of this work was to test the effect of the essential oil (EO) and the ethanolic extract of the aerial parts (TpEtOH) of T. patula on eggs and larvae of H. contortus, through an egg hatch test (EHT) and a larval development test (LDT). In the EHT, the EO showed 100% inhibition at 0.75 mg mL−1 (LC50 = 0.0780 mg mL−1), and the TpEtOH showed 100% inhibition at 100 mg mL−1 (LC50 = 12.8 mg mL−1). In the LDT, the EO showed 100% inhibition at 0.375 mg mL−1 (LC50 = 0.0400 mg mL−1), and the TpEtOH showed 100% inhibition at 1.56 mg mL−1 (LC50 = 0.340 mg mL−1). Compared to available literature data, the results presented here suggest that the crude extracts of T. patula have substantial potential for controlling this nematode by interrupting its life cycle and/or preventing it from reaching the infective stage.

Journal

Chemistry & BiodiversityWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off