Characterization of unusual DS‐1‐like G3P[8] rotavirus strains in children with diarrhea in Japan

Characterization of unusual DS‐1‐like G3P[8] rotavirus strains in children with diarrhea in... INTRODUCTIONGroup A rotavirus (RVA), a member of the genus Rotavirus within the family Reoviridae, is a leading pathogen causing severe diarrhea in young children worldwide. RVA gastroenteritis accounts for ∼215 000 deaths per year among children <5 years old. RVA comprises 11 gene segments of double‐stranded (ds) RNA, encoding six structural proteins (VP1‐VP4, VP6, and VP7) and six non‐structural proteins (NSP1‐NSP6). RVA possesses two outer capsid proteins, VP7 and VP4, which are implicated independently in neutralization, and define the G and P genotypes, respectively. To date, at least 32 G and 47 P genotypes have been assigned by the Rotavirus Classification Working Group (RCWG) (https://rega.kuleuven.be/cev/viralmetagenomics/virus-classification/rcwg). Among them, the 6 G (G1‐G4, G9, and G12) and 3 P (P[4], P[6], and P[8]) genotypes are considered as common genotypes of human RVAs (HuRVAs). Recently, a whole genome‐based genotyping system was proposed based on the assignment of all the 11 genes, where Gx‐P[x]‐Ix‐Rx‐Cx‐Mx‐Ax‐Nx‐Tx‐Ex‐Hx designates the genotypes of the VP7‐VP4‐VP6‐VP1‐VP2‐VP3‐NSP1‐NSP2‐NSP3‐NSP4‐NSP5 genes. The majority of HuRVAs have genes similar in sequence to those of prototype human strain Wa (genogroup 1 genes) or DS‐1 (genogroup 2 genes). The Wa‐like strains are characterized by the following genotypes of backbone genes: I1‐R1‐C1‐M1‐A1‐N1‐T1‐E1‐H1, and tend to possess G/P genotypes G1P[8], G3P[8], G4P[8], G9P[8], http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Virology Wiley
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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0146-6615
eISSN
1096-9071
D.O.I.
10.1002/jmv.25016
Publisher site
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Abstract

INTRODUCTIONGroup A rotavirus (RVA), a member of the genus Rotavirus within the family Reoviridae, is a leading pathogen causing severe diarrhea in young children worldwide. RVA gastroenteritis accounts for ∼215 000 deaths per year among children <5 years old. RVA comprises 11 gene segments of double‐stranded (ds) RNA, encoding six structural proteins (VP1‐VP4, VP6, and VP7) and six non‐structural proteins (NSP1‐NSP6). RVA possesses two outer capsid proteins, VP7 and VP4, which are implicated independently in neutralization, and define the G and P genotypes, respectively. To date, at least 32 G and 47 P genotypes have been assigned by the Rotavirus Classification Working Group (RCWG) (https://rega.kuleuven.be/cev/viralmetagenomics/virus-classification/rcwg). Among them, the 6 G (G1‐G4, G9, and G12) and 3 P (P[4], P[6], and P[8]) genotypes are considered as common genotypes of human RVAs (HuRVAs). Recently, a whole genome‐based genotyping system was proposed based on the assignment of all the 11 genes, where Gx‐P[x]‐Ix‐Rx‐Cx‐Mx‐Ax‐Nx‐Tx‐Ex‐Hx designates the genotypes of the VP7‐VP4‐VP6‐VP1‐VP2‐VP3‐NSP1‐NSP2‐NSP3‐NSP4‐NSP5 genes. The majority of HuRVAs have genes similar in sequence to those of prototype human strain Wa (genogroup 1 genes) or DS‐1 (genogroup 2 genes). The Wa‐like strains are characterized by the following genotypes of backbone genes: I1‐R1‐C1‐M1‐A1‐N1‐T1‐E1‐H1, and tend to possess G/P genotypes G1P[8], G3P[8], G4P[8], G9P[8],

Journal

Journal of Medical VirologyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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