Abstract: (3H)Quipazine was used to label binding sites in rat brain membranes that display characteristics of a 5‐hydroxytryptamine3 (5‐HT3) receptor. The radioligand binds with high affinity (KD, 1.2 ± 0.1 nM) to a saturable population of sites (Bmax, 3.0 ± 0.4 pmol/g of tissue) that are differentially located in the brain. Specific (3H)quipazine binding is not affected by guanine or adenine nucleotides. ICS 205–930, BRL 43964, Lilly 278584, and zacopride display less than nanomolar affinity for these sites whereas MDL 72222 is approximately one order of magnitude less potent. The pharmacological profile of the binding site is in excellent agreement with that of 5‐HT3 receptors characterized in peripheral physiological models. We conclude that (3H)quipazine labels a 5‐HT3 receptor in the rat CNS.
Journal of Neurochemistry – Wiley
Published: Jun 1, 1989
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera