Characterization and Localization of Glutathione‐ S ‐Transferases in Rat Brain and Binding of Hormones, Neurotransmitters, and Drugs

Characterization and Localization of Glutathione‐ S ‐Transferases in Rat Brain and Binding of... Abstract: Rat brain glutathione‐S‐transferases are rich in Yb type subunits with major RNA transcripts coding for a relatively uncommon Yb3 form. The Yb‐containing isoenzymes of brain cytosol bind glucocorticoids and are covalently labeled with dexamethasone 21‐methanesulfonate. Certain neurotransmitters, hormones, and drugs, such as serotonin, dopamine, glucocorticoids, thyroxine, apomorphine, and benzodiazepine derivatives, are effective inhibitors of brain glutathione transferase activity. Immunocytochemical studies show that Yb forms are localized in ependymal cells, subventricular zone cells, astrocytes, tanycytes, and astrocyte foot processes on blood vessels, but Yb was not detected in oligodendrocytes or neurons. Based on their localization and binding properties, brain glutathione‐S‐transferases have the potential to function in intracellular binding of a variety of compounds and thereby govern their uptake and release in brain, transport to neurons, as well as in their detoxification. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

Characterization and Localization of Glutathione‐ S ‐Transferases in Rat Brain and Binding of Hormones, Neurotransmitters, and Drugs

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Publisher
Wiley
Copyright
Copyright © 1988 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3042
eISSN
1471-4159
D.O.I.
10.1111/j.1471-4159.1988.tb13228.x
Publisher site
See Article on Publisher Site

Abstract

Abstract: Rat brain glutathione‐S‐transferases are rich in Yb type subunits with major RNA transcripts coding for a relatively uncommon Yb3 form. The Yb‐containing isoenzymes of brain cytosol bind glucocorticoids and are covalently labeled with dexamethasone 21‐methanesulfonate. Certain neurotransmitters, hormones, and drugs, such as serotonin, dopamine, glucocorticoids, thyroxine, apomorphine, and benzodiazepine derivatives, are effective inhibitors of brain glutathione transferase activity. Immunocytochemical studies show that Yb forms are localized in ependymal cells, subventricular zone cells, astrocytes, tanycytes, and astrocyte foot processes on blood vessels, but Yb was not detected in oligodendrocytes or neurons. Based on their localization and binding properties, brain glutathione‐S‐transferases have the potential to function in intracellular binding of a variety of compounds and thereby govern their uptake and release in brain, transport to neurons, as well as in their detoxification.

Journal

Journal of NeurochemistryWiley

Published: Jan 1, 1988

References

  • Differential immunocytochemical staining of glial fibrillary acidic (GFA) protein, S‐100 protein and glutamine synthetase in the rat subcommissural organ, nonspecialized ventricular ependyma and adjacent neuropil
    Didier, Didier; Harandi, Harandi; Aguera, Aguera; Bancel, Bancel; Tardy, Tardy; Fages, Fages; Calas, Calas; Stagaard, Stagaard; Mollgard, Mollgard; Belin, Belin
  • Oxidized and reduced glutathione in rat brain under normoxic and hypoxic conditions
    Folbergrová, Folbergrová; Rehncrona, Rehncrona; Siesjö, Siesjö

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