INTRODUCTIONInfection is one of the most commonly identified etiologies of acute peripheral facial palsy (APFP). Causative organisms such as Borrelia burgodoferi, Varicella zoster virus (VZV), and Herpes simplex virus (HSV) are often detected in the cerebrospinal fluid of patients with APFP. In the past, reactivation of HSV‐1 was believed to be the main cause of Bell's palsy (BP); however, a recent other study reported a potential association between BP and another HSV, Human herpesvirus 6. Approximately 8‐28% of BP cases is caused by VZV infection, and such cases are classified separately as zoster sine herpete (ZSH).. One of the most‐representative VZV infections—the Ramsay‐Hunt syndrome—presents as a vesicular eruption in the external auditory canal or oropharynx and is sometimes accompanied by vestibulocochlear dysfunction in APFP patients.Although the recent American guidelines recommend against routine laboratory testing, confirmation of reactivated VZV requires laboratory testing, as it is impossible to differentiate ZSH from BP without laboratory testing. This differential diagnosis is important because the dose of antiviral agent required might differ on the basis of the pathogen and the final recovery rate differs between ZSH and BP.For detection of VZV or HSV, the antibody titers against these viruses can be measured by enzyme‐linked
Journal of Medical Virology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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