Characteristic chromosomal abnormalities in biopsies and lymphoid‐cell lines from patients with burkitt and non‐burkitt lymphomas

Characteristic chromosomal abnormalities in biopsies and lymphoid‐cell lines from patients with... The karyotypes of cells from 10 Burkitt lymphoma (BL) biopsies, eight cell lines established from BL and nine cell lines from non‐BL sources were studied by chromosome banding techniques. With the exception of the BL‐derived cell lines BJAB, GC‐BJAB, Maku and U‐8691 all biopsies and lines of Burkitt origin contained an extra band at the distal region of the long arm of one chromosome 14. An extra band on chromosome 14 was also found in cells of one non‐BL biopsy, in cells from a lymphosarcoma‐derived cell line and in a longestablished cell line derived from the pleural exudate of a patient with Hodgkin's disease. A distal region at the long arm of one chromosome 8 was missing in all metaphase figures of good technical quality in the same material. The size, morphology and stainability of missing region corresponded fairly well to the extra region at chromosome 14. We therefore suggest that the chromosome 14 marker represents a translocation between chromosomes 8 and 14,t (8q‐; 14q+). The translocation was present neither in lymphocytes of peripheral blood of five Burkitt patients nor in five lymphoblastoid cell lines of non‐BL origin. Trisomy 7 was found in two of the 10 BL biopsies, in two BL‐derived cell lines, in one non‐BL biopsy, in two lymphosarcoma‐derived cell lines and in one cell line derived from a patient with Hodgkin's disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Cancer Wiley

Characteristic chromosomal abnormalities in biopsies and lymphoid‐cell lines from patients with burkitt and non‐burkitt lymphomas

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Publisher
Wiley
Copyright
Copyright © 1976 Wiley‐Liss, Inc., A Wiley Company
ISSN
0020-7136
eISSN
1097-0215
DOI
10.1002/ijc.2910170108
Publisher site
See Article on Publisher Site

Abstract

The karyotypes of cells from 10 Burkitt lymphoma (BL) biopsies, eight cell lines established from BL and nine cell lines from non‐BL sources were studied by chromosome banding techniques. With the exception of the BL‐derived cell lines BJAB, GC‐BJAB, Maku and U‐8691 all biopsies and lines of Burkitt origin contained an extra band at the distal region of the long arm of one chromosome 14. An extra band on chromosome 14 was also found in cells of one non‐BL biopsy, in cells from a lymphosarcoma‐derived cell line and in a longestablished cell line derived from the pleural exudate of a patient with Hodgkin's disease. A distal region at the long arm of one chromosome 8 was missing in all metaphase figures of good technical quality in the same material. The size, morphology and stainability of missing region corresponded fairly well to the extra region at chromosome 14. We therefore suggest that the chromosome 14 marker represents a translocation between chromosomes 8 and 14,t (8q‐; 14q+). The translocation was present neither in lymphocytes of peripheral blood of five Burkitt patients nor in five lymphoblastoid cell lines of non‐BL origin. Trisomy 7 was found in two of the 10 BL biopsies, in two BL‐derived cell lines, in one non‐BL biopsy, in two lymphosarcoma‐derived cell lines and in one cell line derived from a patient with Hodgkin's disease.

Journal

International Journal of CancerWiley

Published: Jan 15, 1976

References

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