Characterisation of a sucrose‐independent in vitro biofilm model of supragingival plaque

Characterisation of a sucrose‐independent in vitro biofilm model of supragingival plaque INTRODUCTIONMore than 700 species of bacteria inhabit the oral cavity. Dental plaque is a biofilm comprised of multiple species of oral bacteria and extracellular polymeric substances (EPS), and supragingival plaque accumulation is a major cause of caries and periodontal disease (Filoche, Wong, & Sissons, ). It has been reported that the onset/progression of caries is correlated with sugar intake (frequency and interval) (Hujoel, ). Many studies have suggested that Streptococcus mutans is the major pathogen in caries because it produces glucan, which promotes bacterial adhesion to the tooth surface, and excessive acid, which promotes tooth demineralisation, by metabolising a sucrose‐containing dietary source (Kleinberg, ; Paes Leme, Koo, Bellato, Bedi, & Cury, ; Takahashi & Nyvad, ). Therefore, various anticaries agents have been developed to reduce sucrose‐dependent plaque.However, the recent “An extended caries ecological hypothesis” of caries aetiology (Takahashi & Nyvad, ) argues against this predominant role of S. mutans. It posits that mineral changes on the surface of dental hard tissues are the result of increased acidity in the plaque environment due to homeostatic disturbances in the relative proportions of acidogenic/aciduric bacteria, such as Actinomyces and Streptococcus, including S. mutans. According to this theory, S. mutans and sucrose are not essential factors http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Oral Diseases Wiley

Characterisation of a sucrose‐independent in vitro biofilm model of supragingival plaque

Loading next page...
 
/lp/wiley/characterisation-of-a-sucrose-independent-in-vitro-biofilm-model-of-2EbFw8JEnT
Publisher
Wiley
Copyright
Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley &Sons Ltd
ISSN
1354-523X
eISSN
1601-0825
D.O.I.
10.1111/odi.12779
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONMore than 700 species of bacteria inhabit the oral cavity. Dental plaque is a biofilm comprised of multiple species of oral bacteria and extracellular polymeric substances (EPS), and supragingival plaque accumulation is a major cause of caries and periodontal disease (Filoche, Wong, & Sissons, ). It has been reported that the onset/progression of caries is correlated with sugar intake (frequency and interval) (Hujoel, ). Many studies have suggested that Streptococcus mutans is the major pathogen in caries because it produces glucan, which promotes bacterial adhesion to the tooth surface, and excessive acid, which promotes tooth demineralisation, by metabolising a sucrose‐containing dietary source (Kleinberg, ; Paes Leme, Koo, Bellato, Bedi, & Cury, ; Takahashi & Nyvad, ). Therefore, various anticaries agents have been developed to reduce sucrose‐dependent plaque.However, the recent “An extended caries ecological hypothesis” of caries aetiology (Takahashi & Nyvad, ) argues against this predominant role of S. mutans. It posits that mineral changes on the surface of dental hard tissues are the result of increased acidity in the plaque environment due to homeostatic disturbances in the relative proportions of acidogenic/aciduric bacteria, such as Actinomyces and Streptococcus, including S. mutans. According to this theory, S. mutans and sucrose are not essential factors

Journal

Oral DiseasesWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off