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Changes in DNA polymerase activity associated with cell fusion in cultures of embryonic muscle

Changes in DNA polymerase activity associated with cell fusion in cultures of embryonic muscle 10.1002/jcp.1040730109.abs In cultures of differentiating chicken embryo muscle cells there is a steep decline in DNA polymerase activity which closely parallels the time of rapid cell fusion and the formation of multinucleated myotubes. The DNA polymerase activity remaining in the cultures is almost completely associated with single unfused cells. Cell fusion does not require a confluent culture and fusion capability appears to be severely reduced in the remaining single cells following an approximately ten hour time period during which the majority of fusion takes place. A model is presented to explain the observed kinetics of cell growth and cell fusion in vitro. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cellular Physiology Wiley

Changes in DNA polymerase activity associated with cell fusion in cultures of embryonic muscle

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References (16)

Publisher
Wiley
Copyright
Copyright © 1969 Wiley‐Liss, Inc.
ISSN
0021-9541
eISSN
1097-4652
DOI
10.1002/jcp.1040730109
pmid
5765780
Publisher site
See Article on Publisher Site

Abstract

10.1002/jcp.1040730109.abs In cultures of differentiating chicken embryo muscle cells there is a steep decline in DNA polymerase activity which closely parallels the time of rapid cell fusion and the formation of multinucleated myotubes. The DNA polymerase activity remaining in the cultures is almost completely associated with single unfused cells. Cell fusion does not require a confluent culture and fusion capability appears to be severely reduced in the remaining single cells following an approximately ten hour time period during which the majority of fusion takes place. A model is presented to explain the observed kinetics of cell growth and cell fusion in vitro.

Journal

Journal of Cellular PhysiologyWiley

Published: Feb 1, 1969

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