Change of phosphotyrosine immunoreactivity on microglia in the rat substantia nigra following striatal ischemic injury

Change of phosphotyrosine immunoreactivity on microglia in the rat substantia nigra following... Using immunohistochemistry, we investigated changes in phosphotyrosine (P‐Tyr) immunoreactivity on the microglia of the rat substantia nigra (SN) following striatal ischemic injury produced by transient middle cerebral artery (MCA) occlusion. Anterograde axonal degeneration in the SN due to striatal ischemic injury was detected by depletion of calcineurin immunoreactivity in that region from 1 day after operation. From 3 days to 1 month (the longest period examined in this study) after MCA occlusion, there was a significant increase in P‐Tyr immunoreactivity in the SN ipsilateral to the MCA occlusion. Also, light microscopic observation showed that the microglia exhibited an increased immunoreactivity for P‐Tyr and characteristic morphological changes in the ipsilateral SN. The present results indicate that a signal transducing cascade(s) associated with tyrosine phosphorylation may be involved in the activation of the microglia in the SN responding to anterograde degeneration of the striatonigral pathway. © 1995 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Glia Wiley

Change of phosphotyrosine immunoreactivity on microglia in the rat substantia nigra following striatal ischemic injury

Loading next page...
 
/lp/wiley/change-of-phosphotyrosine-immunoreactivity-on-microglia-in-the-rat-WPgKuzeSAu
Publisher site
See Article on Publisher Site

Abstract

Using immunohistochemistry, we investigated changes in phosphotyrosine (P‐Tyr) immunoreactivity on the microglia of the rat substantia nigra (SN) following striatal ischemic injury produced by transient middle cerebral artery (MCA) occlusion. Anterograde axonal degeneration in the SN due to striatal ischemic injury was detected by depletion of calcineurin immunoreactivity in that region from 1 day after operation. From 3 days to 1 month (the longest period examined in this study) after MCA occlusion, there was a significant increase in P‐Tyr immunoreactivity in the SN ipsilateral to the MCA occlusion. Also, light microscopic observation showed that the microglia exhibited an increased immunoreactivity for P‐Tyr and characteristic morphological changes in the ipsilateral SN. The present results indicate that a signal transducing cascade(s) associated with tyrosine phosphorylation may be involved in the activation of the microglia in the SN responding to anterograde degeneration of the striatonigral pathway. © 1995 Wiley‐Liss, Inc.

Journal

GliaWiley

Published: Feb 1, 1995

References

  • Displacement of synaptic terminals from regenerating motoneurons by microglial cells
    Blinzinger, Blinzinger; Kreutzberg, Kreutzberg
  • Interleukin‐1 of the central nervous system is produced by ameboid microglia
    Giulian, Giulian; Baker, Baker; Shih, Shih; Lachman, Lachman
  • Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells
    Graeber, Graeber; Streit, Streit; Kreutzberg, Kreutzberg
  • Increase of macrophage colony‐stimulating factor and granulocyte‐macrophage colony stimulating factor receptors in the regenerating rat facial nucleus
    Raivich, Raivich; Gehrmann, Gehrmann; Kreutzberg, Kreutzberg
  • Functional plasticity of microglia: A review
    Streit, Streit; Graeber, Graeber; Kreutzberg, Kreutzberg

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off