Chagosendines A – C, New Metal Complexes of Imidazole Alkaloids from the Calcareous Sponge Leucetta chagosensis

Chagosendines A – C, New Metal Complexes of Imidazole Alkaloids from the Calcareous Sponge... Chemical examination of the bright yellow sponge Leucetta chagosensis resulted in the isolation of three new imidazole‐based alkaloid complexes namely chagosendines A – C (1 – 3), together with known analogues pyronaamidine, naamidine J, and naamine C. Their structures were determined on the basis of extensive spectroscopic (IR, MS, NMR, and single‐crystal X‐ray diffraction) analysis in association with the chemical conversion. The isolated alkaloids together with three synthesized new homodimer complexes were evaluated for the cytotoxic activities against a panel of tumor cell lines. The copper complexes of imidazole alkaloids 2 and 3, as found from nature for the first time, exerted selective and remarkable activities against the tumor cell lines K562, HepG2, and HeLa. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemistry & Biodiversity Wiley

Chagosendines A – C, New Metal Complexes of Imidazole Alkaloids from the Calcareous Sponge Leucetta chagosensis

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley‐VHCA AG, Zurich, Switzerland
ISSN
1612-1872
eISSN
1612-1880
D.O.I.
10.1002/cbdv.201700481
Publisher site
See Article on Publisher Site

Abstract

Chemical examination of the bright yellow sponge Leucetta chagosensis resulted in the isolation of three new imidazole‐based alkaloid complexes namely chagosendines A – C (1 – 3), together with known analogues pyronaamidine, naamidine J, and naamine C. Their structures were determined on the basis of extensive spectroscopic (IR, MS, NMR, and single‐crystal X‐ray diffraction) analysis in association with the chemical conversion. The isolated alkaloids together with three synthesized new homodimer complexes were evaluated for the cytotoxic activities against a panel of tumor cell lines. The copper complexes of imidazole alkaloids 2 and 3, as found from nature for the first time, exerted selective and remarkable activities against the tumor cell lines K562, HepG2, and HeLa.

Journal

Chemistry & BiodiversityWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ;

References

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