CEREBRAL ANOXIA: EFFECT ON TRANSCRIPTION AND TRANSLATION

CEREBRAL ANOXIA: EFFECT ON TRANSCRIPTION AND TRANSLATION Abstract— The activity of DNA‐dependent RNA polymerase and the synthesis of microsomal protein were investigated after various periods of anoxic condition produced with rabbit brain in an in vitro experimental model. There was prompt inhibition of protein synthesis even after an anoxic period of 5 min, and inhibition was more than 80 per cent after an anoxic period of 30 min. However, RNA polymerase activity was retained during the early stage of anoxia, but definite inhibition appeared after an anoxic period of 15 min. Comparisons with other available information suggest that the inhibition of protein synthesis observed with brain slices is closely related to their polysomal function, that irreversibility of inhibition of protein synthesis might be related to the involvement of nuclear RNA synthesizing mechanism, and that these can occur both in the neuronal and glial elements. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

CEREBRAL ANOXIA: EFFECT ON TRANSCRIPTION AND TRANSLATION

Journal of Neurochemistry, Volume 22 (1) – Jan 1, 1974

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Publisher
Wiley
Copyright
Copyright © 1974 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3042
eISSN
1471-4159
DOI
10.1111/j.1471-4159.1974.tb12186.x
Publisher site
See Article on Publisher Site

Abstract

Abstract— The activity of DNA‐dependent RNA polymerase and the synthesis of microsomal protein were investigated after various periods of anoxic condition produced with rabbit brain in an in vitro experimental model. There was prompt inhibition of protein synthesis even after an anoxic period of 5 min, and inhibition was more than 80 per cent after an anoxic period of 30 min. However, RNA polymerase activity was retained during the early stage of anoxia, but definite inhibition appeared after an anoxic period of 15 min. Comparisons with other available information suggest that the inhibition of protein synthesis observed with brain slices is closely related to their polysomal function, that irreversibility of inhibition of protein synthesis might be related to the involvement of nuclear RNA synthesizing mechanism, and that these can occur both in the neuronal and glial elements.

Journal

Journal of NeurochemistryWiley

Published: Jan 1, 1974

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