Cell death in the normal neonatal rat adrenal cortex

Cell death in the normal neonatal rat adrenal cortex PLATES CLV-CLVIII I N the preceding paper we demonstrated that certain cells deep in the adrenal cortex of adult and foetal rats were deleted by a specific and apparently controlled process on the rapid withdrawal of ACTH stimulation (Wyllie, Kerr, Macaskill and Currie, 1973). This process, referred to as apoptosis (Kerr, Wyllie and Currie, 1972), possesses morphological features and is initiated by hormonal factors of such a kind as to suggest it may play an important role in the normal physiological control of the adrenocortical cell population. Definitive demonstration of such a role is difficult, but a step towards it would be made if it were shown that physiological variations in ACTH secretion modified the rate of adrenocortical apoptosis. This paper describes the changing incidence of adrenocortical apoptosis in the rat over the newborn period, when there is good evidence that ACTH stimulation wanes physiologically; evidence is presented that these changes in incidence are indeed ACTH dependent. MATERIALS METHODS AND Sprague-Dawley rats were killed instantly by cervical transection, without prior treatment and with a minimum of handling, within 2 hr of birth and at 1, 2, 3, 4,5, 7, 14, 21, 28, 35, 42 and 49 days thereafter. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Pathology Wiley

Cell death in the normal neonatal rat adrenal cortex

Loading next page...
 
/lp/wiley/cell-death-in-the-normal-neonatal-rat-adrenal-cortex-Wq25rqbGNr
Publisher site
See Article on Publisher Site

Abstract

PLATES CLV-CLVIII I N the preceding paper we demonstrated that certain cells deep in the adrenal cortex of adult and foetal rats were deleted by a specific and apparently controlled process on the rapid withdrawal of ACTH stimulation (Wyllie, Kerr, Macaskill and Currie, 1973). This process, referred to as apoptosis (Kerr, Wyllie and Currie, 1972), possesses morphological features and is initiated by hormonal factors of such a kind as to suggest it may play an important role in the normal physiological control of the adrenocortical cell population. Definitive demonstration of such a role is difficult, but a step towards it would be made if it were shown that physiological variations in ACTH secretion modified the rate of adrenocortical apoptosis. This paper describes the changing incidence of adrenocortical apoptosis in the rat over the newborn period, when there is good evidence that ACTH stimulation wanes physiologically; evidence is presented that these changes in incidence are indeed ACTH dependent. MATERIALS METHODS AND Sprague-Dawley rats were killed instantly by cervical transection, without prior treatment and with a minimum of handling, within 2 hr of birth and at 1, 2, 3, 4,5, 7, 14, 21, 28, 35, 42 and 49 days thereafter.

Journal

The Journal of PathologyWiley

Published: Dec 1, 1973

References

  • Shrinkage necrosis: a distinct mode of cellular death
    Kerr, Kerr
  • Adrenocortical cell deletion: the role of ACTH
    Wyllie, Wyllie; Kerr, Kerr; Macaskill, Macaskill; Currie, Currie

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off