Ceftriaxone and pseudolithiasis in older people

Ceftriaxone and pseudolithiasis in older people Dear Editor,Japan is one of the fastest aging countries in the world. The need for intravenous administration of ceftriaxone (CTRX) to older people will continue to increase as a result of various age‐related infections, such as pneumonia and urinary tract infections. For this reason, we report two cases that highlight the occurrences of CTRX‐induced pseudolithiasis during CTRX administration to older people.A 78‐year‐old woman was admitted because she was losing consciousness and was unable to eat due to a high pyrexia of 40°C. We diagnosed a septic state (a rapid increase in inflammatory response and 2 points on the sequential [sepsis‐related] organ failure assessment score [Glasgow Coma Scale 14, creatinine 1.76 mg/mL]) and consequently a group of β‐hemolytic streptococcus in blood culture was detected; the infection probably originated from a stage II (pressure ulcer staging classification) decubitus ulcer at the sacral region. Four grams of CTRX was administered intravenously by drip for 20 days. Regular blood analysis on day 29 showed an elevation of alkaline phosphatase to 1049 IU/L and a lactate dehydrogenase level of 287 IU/L, although she had no complaints, such as abdominal pain. Computed tomography (CT) showed a biliary stone, and sludge in the bile duct and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Geriatrics & Gerontology International Wiley

Ceftriaxone and pseudolithiasis in older people

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Japan Geriatrics Society
ISSN
1444-1586
eISSN
1447-0594
D.O.I.
10.1111/ggi.13245
Publisher site
See Article on Publisher Site

Abstract

Dear Editor,Japan is one of the fastest aging countries in the world. The need for intravenous administration of ceftriaxone (CTRX) to older people will continue to increase as a result of various age‐related infections, such as pneumonia and urinary tract infections. For this reason, we report two cases that highlight the occurrences of CTRX‐induced pseudolithiasis during CTRX administration to older people.A 78‐year‐old woman was admitted because she was losing consciousness and was unable to eat due to a high pyrexia of 40°C. We diagnosed a septic state (a rapid increase in inflammatory response and 2 points on the sequential [sepsis‐related] organ failure assessment score [Glasgow Coma Scale 14, creatinine 1.76 mg/mL]) and consequently a group of β‐hemolytic streptococcus in blood culture was detected; the infection probably originated from a stage II (pressure ulcer staging classification) decubitus ulcer at the sacral region. Four grams of CTRX was administered intravenously by drip for 20 days. Regular blood analysis on day 29 showed an elevation of alkaline phosphatase to 1049 IU/L and a lactate dehydrogenase level of 287 IU/L, although she had no complaints, such as abdominal pain. Computed tomography (CT) showed a biliary stone, and sludge in the bile duct and

Journal

Geriatrics & Gerontology InternationalWiley

Published: Jan 1, 2018

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