1. Extracellular recordings were made from caudate nucleus neurones in decerebrate cats using five‐barrel micropipette electrodes. 2. Electrical stimulation of the substantia nigra caused spike rate depressions in 121 of 260 caudate neurones as evidenced by changes in the post‐stimulus histograms of their firing patterns. Spike rate facilitation occurred with forty‐two caudate units. 3. Neurones depressed by nigral stimuli were consistently depressed by micro‐iontophoretic dopamine. 4. Alpha‐methyldopamine, administered iontophoretically, antagonized the depressant responses induced by both nigral stimulation and iontophoretic dopamine. 5. The data are compatible with the concept that the caudate neuronal depressant responses produced by nigral stimulation are mediated by a direct dopaminergic nigro‐neostriatal pathway. The possibility of mediation via polysynaptic pathways cannot, however, be completely excluded.
The Journal of Physiology – Wiley
Published: Jul 1, 1970
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera