Caudate nucleus neurones: correlation of the effects of substantia nigra stimulation with iontophoretic dopamine

Caudate nucleus neurones: correlation of the effects of substantia nigra stimulation with... 1. Extracellular recordings were made from caudate nucleus neurones in decerebrate cats using five‐barrel micropipette electrodes. 2. Electrical stimulation of the substantia nigra caused spike rate depressions in 121 of 260 caudate neurones as evidenced by changes in the post‐stimulus histograms of their firing patterns. Spike rate facilitation occurred with forty‐two caudate units. 3. Neurones depressed by nigral stimuli were consistently depressed by micro‐iontophoretic dopamine. 4. Alpha‐methyldopamine, administered iontophoretically, antagonized the depressant responses induced by both nigral stimulation and iontophoretic dopamine. 5. The data are compatible with the concept that the caudate neuronal depressant responses produced by nigral stimulation are mediated by a direct dopaminergic nigro‐neostriatal pathway. The possibility of mediation via polysynaptic pathways cannot, however, be completely excluded. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Physiology Wiley

Caudate nucleus neurones: correlation of the effects of substantia nigra stimulation with iontophoretic dopamine

The Journal of Physiology, Volume 208 (3) – Jul 1, 1970

Loading next page...
 
/lp/wiley/caudate-nucleus-neurones-correlation-of-the-effects-of-substantia-FCD034fw4Z
Publisher
Wiley
Copyright
© 2014 The Physiological Society
ISSN
0022-3751
eISSN
1469-7793
DOI
10.1113/jphysiol.1970.sp009143
Publisher site
See Article on Publisher Site

Abstract

1. Extracellular recordings were made from caudate nucleus neurones in decerebrate cats using five‐barrel micropipette electrodes. 2. Electrical stimulation of the substantia nigra caused spike rate depressions in 121 of 260 caudate neurones as evidenced by changes in the post‐stimulus histograms of their firing patterns. Spike rate facilitation occurred with forty‐two caudate units. 3. Neurones depressed by nigral stimuli were consistently depressed by micro‐iontophoretic dopamine. 4. Alpha‐methyldopamine, administered iontophoretically, antagonized the depressant responses induced by both nigral stimulation and iontophoretic dopamine. 5. The data are compatible with the concept that the caudate neuronal depressant responses produced by nigral stimulation are mediated by a direct dopaminergic nigro‐neostriatal pathway. The possibility of mediation via polysynaptic pathways cannot, however, be completely excluded.

Journal

The Journal of PhysiologyWiley

Published: Jul 1, 1970

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off