Catalyst‐ and Initiator‐Free Radical Addition under Mild Conditions: A Macromolecular Conjugation Tool

Catalyst‐ and Initiator‐Free Radical Addition under Mild Conditions: A Macromolecular... A catalyst/initiator‐free radical addition reaction performed under mild conditions (water, 30 °C) with high yields is reported for the first time. This reaction implies simple pH‐mediated alkoxyamine dissociation followed by addition onto olefinic substrates. The versatility and relevance of this selective reaction for macromolecular conjugation and engineering are shown through the syntheses of block copolymers, as well as hydrogels containing in situ‐loaded proteins, which could retain biological activity. This contrasts with standard thermal radical conditions that lead to complete protein inactivation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemistry - A European Journal Wiley

Catalyst‐ and Initiator‐Free Radical Addition under Mild Conditions: A Macromolecular Conjugation Tool

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Publisher
Wiley
Copyright
© 2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN
0947-6539
eISSN
1521-3765
D.O.I.
10.1002/chem.201800035
Publisher site
See Article on Publisher Site

Abstract

A catalyst/initiator‐free radical addition reaction performed under mild conditions (water, 30 °C) with high yields is reported for the first time. This reaction implies simple pH‐mediated alkoxyamine dissociation followed by addition onto olefinic substrates. The versatility and relevance of this selective reaction for macromolecular conjugation and engineering are shown through the syntheses of block copolymers, as well as hydrogels containing in situ‐loaded proteins, which could retain biological activity. This contrasts with standard thermal radical conditions that lead to complete protein inactivation.

Journal

Chemistry - A European JournalWiley

Published: Jan 12, 2018

Keywords: ; ; ; ;

References

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