Case of progressive supranuclear palsy detected by tau imaging with [18F]THK‐5351 before the appearance of characteristic clinical features

Case of progressive supranuclear palsy detected by tau imaging with [18F]THK‐5351 before the... Dear Editor,Progressive supranuclear palsy (PSP) has been recognized as a rare cause of degenerative dementia in older adults in recent times. PSP is a clinical syndrome comprising supranuclear palsy, postural instability and mild dementia. The importance of the accurate identification of patients with PSP lies particularly in the management of its characteristic symptoms. Furthermore, PSP is characterized by deposition of four‐repeat tau isoforms in neuronal and glial inclusions. As is generally known, PSP has various clinical phenotypes. Therefore, initial symptoms of PSP are various, and early diagnosis of PSP is often difficult in the daily clinical setting. A recent study reported that tau imaging positron‐emission tomography (PET), specifically [18F]THK‐5351 PET, can potentially be used to detect the regional brain distribution of tau lesions in PSP.We report a patient with PSP detected by [18F]THK‐5351 PET before the appearance of characteristic clinical features. The patient was a 71‐year‐old right‐handed woman. Amnesic symptoms progressed from 3 years before consultation. The Mini‐Mental State Examination score was 19 out of 30 points at that time. According to the detailed medical history, the main complaint proved to be a language problem. She required substantial effort in speech production, and her spontaneous speech was non‐fluent. Neurological http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Geriatrics & Gerontology International Wiley

Case of progressive supranuclear palsy detected by tau imaging with [18F]THK‐5351 before the appearance of characteristic clinical features

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Publisher
Wiley
Copyright
© 2018 Japan Geriatrics Society
ISSN
1444-1586
eISSN
1447-0594
D.O.I.
10.1111/ggi.13229
Publisher site
See Article on Publisher Site

Abstract

Dear Editor,Progressive supranuclear palsy (PSP) has been recognized as a rare cause of degenerative dementia in older adults in recent times. PSP is a clinical syndrome comprising supranuclear palsy, postural instability and mild dementia. The importance of the accurate identification of patients with PSP lies particularly in the management of its characteristic symptoms. Furthermore, PSP is characterized by deposition of four‐repeat tau isoforms in neuronal and glial inclusions. As is generally known, PSP has various clinical phenotypes. Therefore, initial symptoms of PSP are various, and early diagnosis of PSP is often difficult in the daily clinical setting. A recent study reported that tau imaging positron‐emission tomography (PET), specifically [18F]THK‐5351 PET, can potentially be used to detect the regional brain distribution of tau lesions in PSP.We report a patient with PSP detected by [18F]THK‐5351 PET before the appearance of characteristic clinical features. The patient was a 71‐year‐old right‐handed woman. Amnesic symptoms progressed from 3 years before consultation. The Mini‐Mental State Examination score was 19 out of 30 points at that time. According to the detailed medical history, the main complaint proved to be a language problem. She required substantial effort in speech production, and her spontaneous speech was non‐fluent. Neurological

Journal

Geriatrics & Gerontology InternationalWiley

Published: Jan 1, 2018

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