Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/wiley/carnitine-and-type-2-diabetes-axgBwmaIR6
References (33)
-
G. Mingrone, A. Greco, E. Capristo, G. Benedetti, A. Giancaterini, Andrea Gaetano, G. Gasbarrini (1999)
L-carnitine improves glucose disposal in type 2 diabetic patients.Journal of the American College of Nutrition, 18 1
-
W. Holland, J. Brozinick, Liping Wang, E. Hawkins, Katherine Sargent, Yanqi Liu, Krishna Narra, Kyle Hoehn, T. Knotts, Angela Siesky, D. Nelson, S. Karathanasis, G. Fontenot, M. Birnbaum, S. Summers (2007)
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance.Cell metabolism, 5 3
-
R. Unger (2002)
Lipotoxic diseases.Annual review of medicine, 53
-
F. Stephens, D. Constantin-Teodosiu, P. Greenhaff (2007)
New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscleThe Journal of Physiology, 581
-
A. Arduini, M. Bonomini, V. Savica, A. Amato, V. Zammit (2008)
Carnitine in metabolic disease: potential for pharmacological intervention.Pharmacology & therapeutics, 120 2
-
D. Muoio, T. Koves (2007)
Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1 alpha: implications for metabolic disease.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 32 5
-
Eleuterio Ferrannini, G. Buzzigoli, S. Bevilacqua, C. Boni, D. Chiaro, M. Oleggini, Luigi Brandi, F. Maccari (1988)
Interaction of carnitine with insulin-stimulated glucose metabolism in humans.The American journal of physiology, 255 6 Pt 1
-
D. Sachan, W. Dodson (1992)
Effects of L-carnitine on carbon tetrachloride-induced changes in serum and liver lipids and acylcarnitines.Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 11 3
-
Y. Liang, Y. Li, J. Shan, B. Yu, Z. Ho (1998)
The effects of oral L-carnitine treatment on blood lipid metabolism and the body fat content in the diabetic patient.Asia Pacific journal of clinical nutrition, 7 2
-
S. Long, P. Pekala (1996)
Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes.The Biochemical journal, 319 ( Pt 1)
-
A. Rahbar, R. Shakerhosseini, N. Saadat, F. Taleban, A. Pordal, B. Gollestan (2005)
Effect of L-carnitine on plasma glycemic and lipidemic profile in patients with type II diabetes mellitusEuropean Journal of Clinical Nutrition, 59
-
M. González-Ortiz, S. Hernández-González, E. Hernández-Salazar, E. Martínez-Abundis (2008)
Effect of Oral L-Carnitine Administration on Insulin Sensitivity and Lipid Profile in Type 2 Diabetes Mellitus PatientsAnnals of Nutrition and Metabolism, 52
-
J. McGarry (2001)
Dysregulation of Fatty Acid Metabolism in the Etiology of Type 2 Diabetes -
T. Rhew, D. Sachan (1986)
Dose-dependent lipotropic effect of carnitine in chronic alcoholic rats.The Journal of nutrition, 116 11
-
D. Muoio, T. Koves (2007)
Lipid-induced metabolic dysfunction in skeletal muscle.Novartis Foundation symposium, 286
-
Shulman (2000)
Cellular mechanisms of insulin resistanceJ Clin Invest, 106
-
A. Giancaterini, A. Gaetano, G. Mingrone, D. Gniuli, E. Liverani, E. Capristo, A. Greco (2000)
Acetyl-L-carnitine infusion increases glucose disposal in type 2 diabetic patients.Metabolism: clinical and experimental, 49 6
-
Andrea Gaetano, G. Mingrone, Marco Castagneto, Menotti Calvani (1999)
Carnitine increases glucose disposal in humans.Journal of the American College of Nutrition, 18 4
-
Sachan Ds, Dodson Wl (1992)
Effects of L-carnitine on carbon tetrachloride-induced changes in serum and liver lipids and acylcarnitines.Journal of Environmental Pathology Toxicology and Oncology, 11
-
(2002)
Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction -
J. Chavez, T. Knotts, Liping Wang, Guibin Li, R. Dobrowsky, G. Florant, S. Summers (2003)
A Role for Ceramide, but Not Diacylglycerol, in the Antagonism of Insulin Signal Transduction by Saturated Fatty Acids*The Journal of Biological Chemistry, 278
-
G. Derosa, A. Cicero, A. Gaddi, A. Mugellini, L. Ciccarelli, R. Fogari (2003)
The effect of L-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitus.Clinical therapeutics, 25 5
-
F. Stephens, D. Constantin-Teodosiu, D. Laithwaite, E. Simpson, P. Greenhaff (2006)
An acute increase in skeletal muscle carnitine content alters fuel metabolism in resting human skeletal muscle.The Journal of clinical endocrinology and metabolism, 91 12
-
G. Shulman, Howard
On Diabetes: Insulin Resistance Cellular Mechanisms of Insulin Resistance -
R. Power, M. Hulver, Jingying Zhang, J. Dubois, R. Marchand, O. Ilkayeva, Deborah Muoio, R. Mynatt (2007)
Carnitine revisited: potential use as adjunctive treatment in diabetesDiabetologia, 50
-
D. Kelley, L. Mandarino (2000)
Fuel selection in human skeletal muscle in insulin resistance: a reexamination.Diabetes, 49 5
-
G. Perdomo, S. Commerford, A. Richard, S. Adams, B. Corkey, R. O’Doherty, N. Brown (2004)
Increased β-Oxidation in Muscle Cells Enhances Insulin-stimulated Glucose Metabolism and Protects against Fatty Acid-induced Insulin Resistance Despite Intramyocellular Lipid Accumulation*Journal of Biological Chemistry, 279
-
B. Capaldo, R. Napoli, P. Bonito, Giuseppina Albano, Luigi Saccà (1991)
Carnitine improves peripheral glucose disposal in non-insulin-dependent diabetic patients.Diabetes research and clinical practice, 14 3
-
T. Koves, J. Ussher, R. Noland, D. Slentz, M. Mosedale, O. Ilkayeva, J. Bain, R. Stevens, J. Dyck, C. Newgard, G. Lopaschuk, D. Muoio (2008)
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.Cell metabolism, 7 1
-
L. Ravichandran, D. Esposito, J. Chen, M. Quon (2001)
Protein Kinase C-ζ Phosphorylates Insulin Receptor Substrate-1 and Impairs Its Ability to Activate Phosphatidylinositol 3-Kinase in Response to Insulin*The Journal of Biological Chemistry, 276
-
K. Fea, Richard Roth (1997)
Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.Biochemistry, 36 42
-
David Sebastián, Laura Herrero, D. Serra, G. Asins, F. Hegardt (2007)
CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance.American journal of physiology. Endocrinology and metabolism, 292 3
-
J. McGarry (2002)
Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes.Diabetes, 51 1
- Publisher
- Wiley
- Copyright
- Copyright © 2009 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 1520-7552
- eISSN
- 1520-7560
- DOI
- 10.1002/dmrr.987
- pmid
- 19662615
- Publisher site
- See Article on Publisher Site
Abstract
Studies in humans and animals demonstrate that “lipid over supply” causes or worsens insulin resistance via multiple mechanisms involving the accumulation of intracellular lipids in multiple tissues. In particular, the accumulation of fatty acyl CoA derivatives/metabolites in muscle inhibits both insulin signaling and glucose oxidation. Therefore agents that ameliorate the accumulation of fatty acyl CoA derivatives and/or their metabolites would be beneficial in the treatment or prevention of insulin resistance and T2D.
Journal
Diabetes/Metabolism: Research and Reviews – Wiley
Published: Sep 1, 2009
Keywords: ; ; ;