A17 (P346)Severe hypoglycaemia, cardiovascular outcomes and death: Experience from the ‘Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results’ (LEADER) trialS BAIN1, B Zinman2, SP Marso3, E Christiansen4, S Calanna4, S Rasmussen4, and JB Buse51School of Medicine, University of Swansea, Swansea, UK, 2Lunenfeld–Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Canada, 3Research Medical Center, Kansas City, Missouri, USA, 4Novo Nordisk A/S, Søborg, Denmark, 5University of North Carolina School of Medicine, Chapel Hill, North Carolina, USAAims: In the LEADER cardiovascular (CV) outcomes trial (N = 9,340; NCT01179048), the risk of both CV events and hypoglycaemia was reduced with liraglutide treatment vs placebo, when added to standard of care, in patients with Type 2 diabetes and high risk for CV disease. This post hoc analysis examines potential associations between severe hypoglycaemia and CV events and death.Methods: We analysed time to first major adverse cardiovascular event ([MACE] CV death, non‐fatal myocardial infarction or non‐fatal stroke), CV death and all‐cause death, comparing patients with/without severe hypoglycaemia, and adjusted for different periods of follow‐up and randomised treatment (time‐dependent covariate Cox regression).Results: A total of 267 patients experienced severe hypoglycaemia (liraglutide n = 114, placebo n = 153; rate ratio 0.69; 95% confidence interval [CI] 0.51 to
Diabetic Medicine – Wiley
Published: Jan 1, 2018
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