Cannabinoid Receptor‐Regulated Cyclic AMP Accumulation in the Rat Striatum

Cannabinoid Receptor‐Regulated Cyclic AMP Accumulation in the Rat Striatum : The present study demonstrates that desacetyllevo‐nantradol, a synthetic cannabinoid analog, reduces cyclic AMP levels in rat striatal slices stimulated with vasoactive intestinal peptide or SKF 38393, a D1‐dopamine agonist. Desacetyllevonantradol and the D2 agonist LY 171555 both inhibited D1‐stimulated cyclic AMP accumulation in the striatum. Spipcrone, a specific D2‐dopamine antagonist, fully reversed the inhibitory effect of LY 171555 but not that of desacetyllevonantradol, indicating that this cannabinoid response is not occurring through a D2‐dopaminergic mechanism. Morphine also inhibited cyclic AMP accumulation in striatal slices stimulated with either SKF 38393 or vasoactive intestinal peptide. Naloxone, an opioid antagonist, fully reversed the effect of morphine but not that of desacetyllev‐onantradol, indicating that cannabinoid drugs are not acting via a mechanism involving opioid receptors. The response to maximally effective concentrations of desacetyllevonan‐tradol was not additive to that of maximally effective concentrations of either morphine or LY 171555, suggesting that dopaminergic, opioid, and cannabinoid receptors may be present on the same populations of cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

Cannabinoid Receptor‐Regulated Cyclic AMP Accumulation in the Rat Striatum

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Publisher
Wiley
Copyright
Copyright © 1991 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3042
eISSN
1471-4159
DOI
10.1111/j.1471-4159.1991.tb06379.x
Publisher site
See Article on Publisher Site

Abstract

: The present study demonstrates that desacetyllevo‐nantradol, a synthetic cannabinoid analog, reduces cyclic AMP levels in rat striatal slices stimulated with vasoactive intestinal peptide or SKF 38393, a D1‐dopamine agonist. Desacetyllevonantradol and the D2 agonist LY 171555 both inhibited D1‐stimulated cyclic AMP accumulation in the striatum. Spipcrone, a specific D2‐dopamine antagonist, fully reversed the inhibitory effect of LY 171555 but not that of desacetyllevonantradol, indicating that this cannabinoid response is not occurring through a D2‐dopaminergic mechanism. Morphine also inhibited cyclic AMP accumulation in striatal slices stimulated with either SKF 38393 or vasoactive intestinal peptide. Naloxone, an opioid antagonist, fully reversed the effect of morphine but not that of desacetyllev‐onantradol, indicating that cannabinoid drugs are not acting via a mechanism involving opioid receptors. The response to maximally effective concentrations of desacetyllevonan‐tradol was not additive to that of maximally effective concentrations of either morphine or LY 171555, suggesting that dopaminergic, opioid, and cannabinoid receptors may be present on the same populations of cells.

Journal

Journal of NeurochemistryWiley

Published: Nov 1, 1991

References

  • Cannabinoid receptors and modulation of cyclic AMP accumulation in the rat brain
    Bidaut‐Russell, Bidaut‐Russell; Devane, Devane; Howlett, Howlett

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