Cannabinoid receptor agonists inhibit Ca current in NG108–15 neuroblastoma cells via a Pertussis toxin‐sensitive mechanism

Cannabinoid receptor agonists inhibit Ca current in NG108–15 neuroblastoma cells via a... Cannabinoid receptor ligands irreversibly inhibited peak voltage‐activated Ca currents (44%) in NG108–15 cells; this inhibition was Pertussis toxin‐sensitive. Inhibition was largely due to a reduction in the ω‐conotoxin sensitive portion of high‐voltage activated (HVA) current, although there was also a significant decrease in low‐voltage activated current (56%) and in the nifedipine‐sensitive portion of HVA current (41%). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

Cannabinoid receptor agonists inhibit Ca current in NG108–15 neuroblastoma cells via a Pertussis toxin‐sensitive mechanism

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Abstract

Cannabinoid receptor ligands irreversibly inhibited peak voltage‐activated Ca currents (44%) in NG108–15 cells; this inhibition was Pertussis toxin‐sensitive. Inhibition was largely due to a reduction in the ω‐conotoxin sensitive portion of high‐voltage activated (HVA) current, although there was also a significant decrease in low‐voltage activated current (56%) and in the nifedipine‐sensitive portion of HVA current (41%).

Journal

British Journal of PharmacologyWiley

Published: Jun 1, 1992

References

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