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Cannabinoid receptor agonists inhibit Ca current in NG108–15 neuroblastoma cells via a Pertussis toxin‐sensitive mechanism

Cannabinoid receptor agonists inhibit Ca current in NG108–15 neuroblastoma cells via a Pertussis... Cannabinoid receptor ligands irreversibly inhibited peak voltage‐activated Ca currents (44%) in NG108–15 cells; this inhibition was Pertussis toxin‐sensitive. Inhibition was largely due to a reduction in the ω‐conotoxin sensitive portion of high‐voltage activated (HVA) current, although there was also a significant decrease in low‐voltage activated current (56%) and in the nifedipine‐sensitive portion of HVA current (41%). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

Cannabinoid receptor agonists inhibit Ca current in NG108–15 neuroblastoma cells via a Pertussis toxin‐sensitive mechanism

British Journal of Pharmacology , Volume 106 (2) – Jun 1, 1992

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Publisher
Wiley
Copyright
1992 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1111/j.1476-5381.1992.tb14321.x
Publisher site
See Article on Publisher Site

Abstract

Cannabinoid receptor ligands irreversibly inhibited peak voltage‐activated Ca currents (44%) in NG108–15 cells; this inhibition was Pertussis toxin‐sensitive. Inhibition was largely due to a reduction in the ω‐conotoxin sensitive portion of high‐voltage activated (HVA) current, although there was also a significant decrease in low‐voltage activated current (56%) and in the nifedipine‐sensitive portion of HVA current (41%).

Journal

British Journal of PharmacologyWiley

Published: Jun 1, 1992

References