Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor‐independent mechanism

Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor‐independent... We evaluated the ability of cannabidiol (CBD) to impair the migration of tumor cells stimulated by conditioned medium. CBD caused concentration‐dependent inhibition of the migration of U87 glioma cells, quantified in a Boyden chamber. Since these cells express both cannabinoid CB1 and CB2 receptors in the membrane, we also evaluated their engagement in the antimigratory effect of CBD. The inhibition of cell was not antagonized either by the selective cannabinoid receptor antagonists SR141716 (CB1) and SR144528 (CB2) or by pretreatment with pertussis toxin, indicating no involvement of classical cannabinoid receptors and/or receptors coupled to Gi/o proteins. These results reinforce the evidence of antitumoral properties of CBD, demonstrating its ability to limit tumor invasion, although the mechanism of its pharmacological effects remains to be clarified. British Journal of Pharmacology (2005) 144, 1032–1036. doi:10.1038/sj.bjp.0706134 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor‐independent mechanism

Loading next page...
 
/lp/wiley/cannabidiol-inhibits-human-glioma-cell-migration-through-a-cannabinoid-gR0oEi08du
Publisher
Wiley
Copyright
2005 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
D.O.I.
10.1038/sj.bjp.0706134
Publisher site
See Article on Publisher Site

Abstract

We evaluated the ability of cannabidiol (CBD) to impair the migration of tumor cells stimulated by conditioned medium. CBD caused concentration‐dependent inhibition of the migration of U87 glioma cells, quantified in a Boyden chamber. Since these cells express both cannabinoid CB1 and CB2 receptors in the membrane, we also evaluated their engagement in the antimigratory effect of CBD. The inhibition of cell was not antagonized either by the selective cannabinoid receptor antagonists SR141716 (CB1) and SR144528 (CB2) or by pretreatment with pertussis toxin, indicating no involvement of classical cannabinoid receptors and/or receptors coupled to Gi/o proteins. These results reinforce the evidence of antitumoral properties of CBD, demonstrating its ability to limit tumor invasion, although the mechanism of its pharmacological effects remains to be clarified. British Journal of Pharmacology (2005) 144, 1032–1036. doi:10.1038/sj.bjp.0706134

Journal

British Journal of PharmacologyWiley

Published: Apr 1, 2005

References

  • Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
    BISOGNO, BISOGNO; HANUS, HANUS; PETROCELLIS, PETROCELLIS; TCHILIBON, TCHILIBON; PONDE, PONDE; BRANDI, BRANDI; MORIELLO, MORIELLO; DAVIS, DAVIS; MECHOULAM, MECHOULAM; DI MARZO, DI MARZO
  • Endocannabinoids in the immune system and cancer
    PAROLARO, PAROLARO; MASSI, MASSI; RUBINO, RUBINO; MONTI, MONTI
  • Effects of delta‐9‐tetrahydrocannabinol on human immune function and host defense
    ROTH, ROTH; BALDWIN, BALDWIN; TASHKIN, TASHKIN

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off