Calcium absorption in women: Relationships to Calcium intake, Estrogen status, and age

Calcium absorption in women: Relationships to Calcium intake, Estrogen status, and age A total of 526 absorption studies, using both the double‐isotope and balance‐based methods, were performed in 189 middle‐aged women in good general health. The study extended over 17 years of observation, with most subjects studied from two to four times at 5 year intervals. Each study was done on the woman's own self‐selected calcium intake and was carried out under inpatient, metabolic balance controls. There was a highly significant inverse correlation between calcium intake and absorption fraction, with the best fit provided by an hyperbola in which absorption fraction is approximately inversely proportional to the square root of intake. The range of absorptive performance was very broad at all intake levels. Mean absorption fraction declined from a value of 0.45 at very low intakes (approximately 200 mg Ca per day) to approximately 0.15 at intakes above 2000 mg/day. There was a highly significant fall in absorption efficiency with age, amounting to approximately 0.0021 per year and a one‐time decrease, amounting to approximately 0.022 at the time of menopausal estrogen loss. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Bone and Mineral Research Wiley

Calcium absorption in women: Relationships to Calcium intake, Estrogen status, and age

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Publisher
Wiley
Copyright
Copyright © 1989 ASBMR
ISSN
0884-0431
eISSN
1523-4681
DOI
10.1002/jbmr.5650040404
pmid
2816496
Publisher site
See Article on Publisher Site

Abstract

A total of 526 absorption studies, using both the double‐isotope and balance‐based methods, were performed in 189 middle‐aged women in good general health. The study extended over 17 years of observation, with most subjects studied from two to four times at 5 year intervals. Each study was done on the woman's own self‐selected calcium intake and was carried out under inpatient, metabolic balance controls. There was a highly significant inverse correlation between calcium intake and absorption fraction, with the best fit provided by an hyperbola in which absorption fraction is approximately inversely proportional to the square root of intake. The range of absorptive performance was very broad at all intake levels. Mean absorption fraction declined from a value of 0.45 at very low intakes (approximately 200 mg Ca per day) to approximately 0.15 at intakes above 2000 mg/day. There was a highly significant fall in absorption efficiency with age, amounting to approximately 0.0021 per year and a one‐time decrease, amounting to approximately 0.022 at the time of menopausal estrogen loss.

Journal

Journal of Bone and Mineral ResearchWiley

Published: Aug 1, 1989

References

  • Calcium malabsorption in the elderly: The effect of treatment with oral 25‐hydroxyvitamin D 3
    Francis, Francis; Peacock, Peacock; Storer, Storer; Davies, Davies; Brown, Brown; Nordin, Nordin
  • Menopausal changes in calcium balance performance
    Heaney, Heaney; Recker, Recker; Saville, Saville

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