BRAIN TRYPTOPHAN METABOLISM ON THE 5‐HYDROXYTRYPTAMINE AND KYNURENINE PATHWAYS IN A STRAIN OF RATS WITH A DEFICIENCY IN PLATELET 5‐HT

BRAIN TRYPTOPHAN METABOLISM ON THE 5‐HYDROXYTRYPTAMINE AND KYNURENINE PATHWAYS IN A STRAIN OF... 1 Brain 5‐hydroxytryptamine (5‐HT) metabolism has been compared in albino (Sprague‐Dawley; SD) and in Fawn‐Hooded (FH) rats, which have an inherited platelet 5‐HT deficiency. 2 It was confirmed that blood 5‐HT levels in the FH rats were about one quarter of those in the SD rats. 3 Brain 5‐HT and 5‐HIAA were however higher in FH rats on a per gram basis; there was no difference between the strains on a per brain basis, because of the smaller brain weights of the FH rats. 4 Brain and plasma tryptophan were not significantly different in the two strains. Plasma kynur‐enine was higher in the FH rats, and brain kynurenine was also higher either on a per gram or on a per brain basis. 5 The reserpine‐releasable brain 5‐HT was the same proportion of total brain 5‐HT in the two strains. 6 Experiments with pargyline suggested that the turnover of 5‐HT was somewhat higher in the FH rats on a per gram basis, but not significantly so on a per brain basis. 7 It is concluded that although brain tryptophan metabolism may be somewhat accelerated along both the 5‐HT and kynurenine pathways in the FH rats there is no gross deficiency in the binding of 5‐HT in their brains analogous to that found in their platelets. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

BRAIN TRYPTOPHAN METABOLISM ON THE 5‐HYDROXYTRYPTAMINE AND KYNURENINE PATHWAYS IN A STRAIN OF RATS WITH A DEFICIENCY IN PLATELET 5‐HT

British Journal of Pharmacology, Volume 63 (3) – Jul 1, 1978

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Publisher
Wiley
Copyright
1978 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1111/j.1476-5381.1978.tb07808.x
Publisher site
See Article on Publisher Site

Abstract

1 Brain 5‐hydroxytryptamine (5‐HT) metabolism has been compared in albino (Sprague‐Dawley; SD) and in Fawn‐Hooded (FH) rats, which have an inherited platelet 5‐HT deficiency. 2 It was confirmed that blood 5‐HT levels in the FH rats were about one quarter of those in the SD rats. 3 Brain 5‐HT and 5‐HIAA were however higher in FH rats on a per gram basis; there was no difference between the strains on a per brain basis, because of the smaller brain weights of the FH rats. 4 Brain and plasma tryptophan were not significantly different in the two strains. Plasma kynur‐enine was higher in the FH rats, and brain kynurenine was also higher either on a per gram or on a per brain basis. 5 The reserpine‐releasable brain 5‐HT was the same proportion of total brain 5‐HT in the two strains. 6 Experiments with pargyline suggested that the turnover of 5‐HT was somewhat higher in the FH rats on a per gram basis, but not significantly so on a per brain basis. 7 It is concluded that although brain tryptophan metabolism may be somewhat accelerated along both the 5‐HT and kynurenine pathways in the FH rats there is no gross deficiency in the binding of 5‐HT in their brains analogous to that found in their platelets.

Journal

British Journal of PharmacologyWiley

Published: Jul 1, 1978

References

  • Serotonin and central nervous system function
    Chase, Chase; Murphy, Murphy
  • Variation in hydroxytryptamine metabolism in the rat: effects on the neurochemical response to phencyclidine
    Tonge, Tonge; Leonard, Leonard

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